Deoxygenative cross-coupling of aryl ketones with (Hetero)arenes mediated by a TiCl4/Ammonia borane system

被引：0

作者：

Zang, Yong-jun ^{[1
]}

Zhou, Shi-jie ^{[1
]}

Qian, Chen ^{[1
]}

Xu, Qi-lin ^{[1
]}

Li, Guo-si ^{[1
]}

Li, Xing ^{[2
]}

Zhu, Fu-cheng ^{[1
]}

机构：

[1] West Anhui Univ, Dept Biol & Pharmaceut Engn, Anhui Prov Key Lab Qual Evaluat & Improvement Trad, Luan 237012, Anhui, Peoples R China

[2] Taizhou Univ, Lege Pharm & Chem & Chem Engn, Taizhou 225300, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2024年 / 163卷

基金：

中国国家自然科学基金;

关键词：

Deoxygenative coupling; Aromatic ketones; Ammonia borane; Titanium tetrachloride; FRIEDEL-CRAFTS ALKYLATION; REDUCTIVE ALKYLATION; ARENES; TRIARYLMETHANES; INDOLES;

D O I：

10.1016/j.tet.2024.134147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and mild protocol for the direct deoxygenative coupling of aryl ketones with electron-rich (hetero) arenes to construct the C(sp2)- 2 )- C(sp3) 3 ) bond was achieved, which was mediated by TiCl4 4 and by using ammonia borane (AB) as the reductant. This strategy provides a novel protocol for the synthesis of unsymmetrical diaryland triarylmethanes.

引用

页数：6

共 42 条

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[42] Nano copper oxide mediated ligand-free C-S cross-coupling and concomitant oxidative aromatization of 4-aryl-3,4-dihydropyrimidin-2(1H)-thione with diaryliodonium salts
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