Xylose Incorporated in Unsymmetrical Gold(I) N-Heterocyclic Carbene Complexes: Synthesis, Characterization and Antibacterial Activity

被引：0

作者：

Pascual, Laura M. H. ^{[1
]}

Colin, Marius ^{[2
]}

Mohamadou, Aminou ^{[1
]}

Kowandy, Christelle ^{[1
]}

Plantier-Royon, Richard ^{[1
]}

Gatard, Sylvain ^{[1
]}

机构：

[1] Univ Reims, CNRS, ICMR, F-51687 Reims 2, France

[2] Univ Reims, BIOS, F-51100 Reims, France

来源：

CHEMMEDCHEM | 2024年

关键词：

Antibacterial; Complexes; Gold; N-heterocyclic carbene; Xylose; INHIBITION;

D O I：

10.1002/cmdc.202400245

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of Au(I) complexes containing unsymmetrical N-heterocyclic carbene (imidazolylidene and benzimidazolylidene) functionalized with a xyloside group and an alkyl moiety (methyl and mesityl) was prepared using efficient procedures from D-xylose. Their characterization was carried out in solution by multinuclear NMR, HR-MS spectrometry and cyclic voltammetry, as well as in the solid state by means of single crystal X-ray diffraction analysis for two of them. Evaluation of their ability to inhibit bacterial growth showed a preference for a Gram-positive strain, Staphylococcus aureus, over a Gram-negative strain, Pseudomonas aeruginosa.

引用

页数：6

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