Predictive utility of the impedance drop on AF recurrence using digital intraprocedural data linked to electronic health record data

BACKGROUND Local impedance drop in cardiac tissue during catheter ablation may be a valuable measure to guide atrial fi brillation (AF) ablation procedures for greater effectiveness. OBJECTIVE The study sought to assess whether local impedance drop during catheter ablation to treat AF predicts 1 -year AF recurrence and what threshold of impedance drop is most predictive. METHODS We identi fi ed patients with AF undergoing catheter ablation in the Mercy healthcare system. We downloaded AF ablation procedural data recorded by the CARTO system from a cloud -based analytical tool (CARTONET) and linked them to individual patient electronic health records. Average impedance drops in anatomical region of right and left pulmonary veins were calculated. Effectiveness was measured by a composite outcome of repeat ablation, AF rehospitalization, direct current cardioversion, or initialization of a new antiarrhythmic drug post -blanking period. The association between impedance drop and 1 -year AF recurrence was assessed by logistic regression adjusting for demographics, clinical, and ablation characteristics. Bootstrapping was used to determine the most predictive threshold for impedance drop based on the Youden index. RESULTS Among 242 patients, 23.6% (n 5 57) experienced 1 -year AF recurrence. Patients in the lower third vs upper third of average impedance drop had a 5.9 -fold (95% con fi dence interval [CI] 1.81 -21.8) higher risk of recurrence (37.0% vs 12.5%). The threshold of 7.2 id (95% CI 5.75 -7.7 id) impedance drop best predicted AF recurrence, with sensitivity of 0.73 and positive predictive value of 0.33. Patients with impedance drop <= 7.2 id had 3.5 -fold (95% CI 1.39 -9.50) higher risk of recurrence than patients with impedance drop . 7.2 id, and there was no statistical difference in adverse events between the 2 groups of patients. Sensitivity analysis on right and left wide antral circumferential ablation impedance drop was consistent. CONCLUSION Average impedance drop is a strong predictor of clinical success in reducing AF recurrence but as a single criterion for predicting recurrence only reached 73% sensitivity and 33% positive predictive value.