Transition-Metal-Free C-H Trifluoromethylthiolation of N,N-Disubstituted Enaminones To Access CF3S-Functionalized Enaminones and Their Application in the Synthesis of CF3S-Heteroaryls

被引：6

作者：

Ying, Jinbiao ^{[1
]}

Zhou, Tao ^{[1
]}

Liu, Yunyun ^{[1
]}

Zhou, Liyun ^{[1
]}

Wan, Jie-Ping ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330033, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 12期

基金：

中国国家自然科学基金;

关键词：

BOND FORMATION; FUNCTIONALIZATION; ACYLOXYLATION; AMINES;

D O I：

10.1021/acs.joc.4c00704

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alpha-C-H trifluoromethylthiolation of N,N-disubstituted enaminones has been achieved with simple and cheap CF3SO2Na as the CF3S source. The reactions were run at mild temperature (0 degrees C to rt) using POCl3 as the only reducing reagent. The work represents the first example on the synthesis of alpha-trifluoromethylthio enaminones via direct C-H functionalization. In addition, the resulting CF3S-functionalized enaminones have been proven as useful building blocks in the synthesis of various CF3S-functionalized heteroaromatic compounds by simple annulation reactions.

引用

页码：9078 / 9085

页数：8

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