Synthesis of axially chiral biaryls via Pd(<sc>ii</sc>)-catalysed direct C(sp2)-H arylation

被引：3
|
作者：
Parmar, Diksha [1 ,2 ]
Kumar, Rohit [1 ,2 ]
Sharma, Akhilesh K. [3 ]
Sharma, Upendra [1 ,2 ]
机构：
[1] CSIR IHBT, Chem Technol Div, CH Activat & Phytochem Lab, Palampur 176061, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
[3] Barcelona Inst Sci & Technol BIST, Inst Chem Res Catalonia ICIQ CERCA, Avgda Paisos Catalans 16, Tarragona 43007, Spain
来源：
ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 18期
关键词：
C-H OLEFINATION; LIGANDS; BONDS; ACTIVATION; CHEMISTRY;
D O I：
10.1039/d4qo00958d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, a concise protocol for the construction of axially chiral biaryls via Pd-catalysed direct C-H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using a commercially available, cost-effective, and bench-stable chiral mono-protected amino acid has been uncovered. The high conformational stability of the axially chiral products in different solvents and at high temperatures, as observed from the experimental studies and DFT calculations, shows their excellent stability.
引用
收藏
页码：4986 / 4991
页数：7
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