Comprehensive in silico analysis of prognostic and immune infiltrates for FGFs in human ovarian cancer

被引:0
|
作者
Wang, Yu [1 ]
Zhang, Haiyue [2 ,3 ]
Zhan, Yuanyuan [4 ]
Li, Zhuoran [1 ]
Li, Sujing [5 ]
Guo, Shubin [1 ]
机构
[1] Capital Med Univ, Beijing Chao yang Hosp, Emergency Med Clin Res Ctr, Beijing Key Lab Cardiopulm Cerebral Resuscitat, Beijing 100020, Peoples R China
[2] Capital Med Univ, Beijing Jishuitan Hosp, Thrombosis Res Ctr, Beijing 100035, Peoples R China
[3] Capital Med Univ, Beijing Jishuitan Hosp, Dept Clin Lab, Beijing 100035, Peoples R China
[4] Capital Med Univ, Beijing Chao Yang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China
[5] Zhengzhou First Peoples Hosp, Dept Plast Surg, Zhengzhou, Peoples R China
关键词
Ovarian cancer; Fibroblast growth factors; Prognostic value; Bioinformatics analysis; Tumor microenvironment; FIBROBLAST GROWTH-FACTORS; DNA METHYLATION SIGNATURES; INITIATING CELLS; WEB SERVER; EXPRESSION; PROLIFERATION; WOMEN; GENE; AGGRESSIVENESS; PROGRESSION;
D O I
10.1186/s13048-024-01496-z
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
BackgroundFibroblast growth factors (FGFs) are cell signaling proteins that perform multiple biological processes in many biological processes (cell development, repair, and metabolism). The dynamics of tumor cells, such as angiogenesis, transformation, and proliferation, have a significant impact on neoplasia and are modulated by FGFs. FGFs' expression and prognostic significance in ovarian cancer (OC), however, remain unclear.MethodsThrough a series of in silico analysis, we investigated the transcriptional, survival data, genetic variation, gene-gene interaction network, ferroptosis-related genes, and DNA methylation of FGFs in OC patients.ResultsWe discovered that while FGF18 expression levels were higher in OC tissues than in normal OC tissues, FGF2/7/10/17/22 expression levels were lower in the former, and that FGF1/19 expression was related to the tumor stage in OC patients. According to the survival analysis, the clinical prognosis of individuals with OC was associated with the aberrant expression of FGFs. The function of FGFs and their neighboring genes was mainly connected to the cellular response to FGF stimulus. There was a negative correlation between FGF expression and various immune cell infiltration.ConclusionsThis study clarifies the relationship between FGFs and OC, which might provide new insights into the choice of prognostic biomarkers of OC patients.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] A Comprehensive Analysis of Prognostic Indicators in Serous Ovarian Cancer Based on Leukocyte Migration and Immune Microenvironment
    Pan, Junping
    Chen, Xiaochuan
    Yang, Lin
    Song, Yanwen
    Liu, Jing
    Li, Li
    Lin, Yibin
    Tang, Lina
    Qiu, Sufang
    Xu, Qin
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2023, 28 (06):
  • [22] An Integrative Analysis Revealing ZFHX4-AS1 as a Novel Prognostic Biomarker Correlated with Immune Infiltrates in Ovarian Cancer
    Huang, Changchang
    Cui, Hongyin
    Lang, Xiaolin
    Zhao, Fen
    JOURNAL OF IMMUNOLOGY RESEARCH, 2022, 2022
  • [23] An Integrative Analysis Revealing ZFHX4-AS1 as a Novel Prognostic Biomarker Correlated with Immune Infiltrates in Ovarian Cancer
    Huang, Changchang
    Cui, Hongyin
    Lang, Xiaolin
    Zhao, Fen
    JOURNAL OF IMMUNOLOGY RESEARCH, 2022, 2022
  • [24] Comprehensive Analysis of Prognostic Factors and Immune Infiltration in the CMTMs Family in Human Pancreatic Cancer
    Sun, Ting
    Wang, Ting
    Shi, Wenjing
    Peng, Jun
    Xu, Panling
    Li, Ping
    Zhu, Juan
    Liu, Bin
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2024, 38 (03): : 1999 - 2012
  • [25] Comprehensive Analysis of Tumor Microenvironment Identified Prognostic Immune-Related Gene Signature in Ovarian Cancer
    Li, Na
    Li, Biao
    Zhan, Xianquan
    FRONTIERS IN GENETICS, 2021, 12
  • [26] CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its Association with Immune Infiltrates in Ovarian Cancer
    Hu, Pan
    Lei, Li
    Wang, Ying
    Tian, Xue
    Wei, Xia
    Jiang, Ni
    Liu, Lubin
    MEDIATORS OF INFLAMMATION, 2023, 2023
  • [27] Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer
    Sun, Xiaodan
    Wang, Shouhan
    Li, Qingchang
    FRONTIERS IN GENETICS, 2019, 10
  • [28] Comprehensive Analysis of YTHDF1 Immune Infiltrates and ceRNA in Human Esophageal Carcinoma
    Liu, Xu-Sheng
    Kui, Xue-Yan
    Gao, Yan
    Chen, Xue-Qin
    Zeng, Jing
    Liu, Xiao-Yu
    Zhang, Yu
    Zhang, Yao-Hua
    Pei, Zhi-Jun
    FRONTIERS IN GENETICS, 2022, 13
  • [29] Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas
    Silva Ferreira, Wallax Augusto
    Freire Vitiello, Glauco Akelinghton
    Medina, Tiago da Silva
    Correa de Oliveira, Edivaldo Herculano
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [30] Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas
    Wallax Augusto Silva Ferreira
    Glauco Akelinghton Freire Vitiello
    Tiago da Silva Medina
    Edivaldo Herculano Correa de Oliveira
    Scientific Reports, 12