Proton Pump Inhibitors Induced Hyponatremia in a Liver Transplanted Patient-The Role of Deprescribing: A Case Report and Literature Review

被引：1

作者：

Marciano, Gianmarco ^{[1
]}

Caroleo, Benedetto ^{[2
]}

Catarisano, Luca ^{[1
]}

Cocchis, Donatella ^{[3
]}

Palleria, Caterina ^{[1
,4
]}

De Sarro, Giovambattista ^{[1
,4
]}

Gallelli, Luca ^{[1
,4
]}

机构：

[1] Renato Dulbecco Univ Hosp, Operat Unit Pharmacol & Pharmacovigilance, I-88100 Catanzaro, Italy

[2] Soverato Hosp, Operat Unit Internal Med, ASP7 Catanzaro, I-88100 Catanzaro, Italy

[3] Citta Salute Hosp, Dept Liver Transplants, I-10126 Turin, Italy

[4] Magna Graecia Univ Catanzaro, Res Ctr FASUMG, Dept Hlth Sci, I-88100 Catanzaro, Italy

来源：

REPORTS | 2024年 / 7卷 / 02期

关键词：

liver transplant; immunosuppressants; deprescribing; adverse drug reaction; hyponatremia; pantoprazole; MILD HYPONATREMIA; RISK;

D O I：

10.3390/reports7020033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Liver transplant patients are frail subjects due to lifelong therapy with immunosuppressants. In these patients, comorbidity and polytherapy increase the risk of adverse drug reactions. In this study, we report the development of hyponatremia, probably related to pantoprazole in a liver transplant patient. Sertraline dismission and treatment with sodium chloride did not improve clinical symptoms and laboratory levels. Pantoprazole dismission induced an improvement in clinical symptoms and the normalization of sodium levels. A five-month follow-up revealed the absence of clinical symptoms and normal serum sodium levels.

引用

页数：7

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