Fibrous Dysplasia of the Parietal Bone with Focal Motor Seizures: A Case Report

被引:0
|
作者
Pham, Tuan Anh [2 ]
Nguyen, Duc Hue [2 ]
Ngo, Hanh Thi Tuyet [1 ,3 ]
Le, Minh-An Thuy [1 ,4 ]
机构
[1] Univ Med & Pharm Ho Chi Minh City, Fac Med, Ho Chi Minh City, Vietnam
[2] Nguyen Tri Phuong Hosp, Dept Neurosurg, Ho Chi Minh City, Vietnam
[3] Nguyen Tri Phuong Hosp, Dept Pathol, Ho Chi Minh City, Vietnam
[4] Nguyen Tri Phuong Hosp, Dept Neurol, Ho Chi Minh City, Vietnam
来源
AMERICAN JOURNAL OF CASE REPORTS | 2024年 / 25卷
关键词
Case Reports; Craniofacial Fibrous Dysplasia; Epilepsies; Partial; Bone Diseases; Seizures; SKULL;
D O I
10.12659/AJCR.943718
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Patient: Female, 18-year-old Final Diagnosis: Fibrous dysplasia Symptoms: Seizure Clinical Procedure: - Specialty: Neurology center dot Neurosurgery Objective: Rare disease Background: Monostotic fibrous dysplasia is a benign proliferation of fibrous and osseous tissues that expand medullary bone to cause symptoms due to compression of adjacent organs and anatomical structures. Focal seizures are rarely the first sign of this kind of lesion. This report describes a young female patient with left-sided focal motor seizures associated with fibrous dysplasia presenting as a mass in the right parietal bone. Case Report: An 18-year-old female student with left-sided focal motor seizures presented with a mass in the right parietal bone. Computed tomography revealed an expansile mixed-density lesion on the right parietal bone, a relatively homogeneous ground-glass appearance in the outer circumferential portion, and a lucent eccentric area with thinned but sclerotic borders. Magnetic resonance imaging revealed a homogeneously hypointense signal on T1WI, a small hyperintense signal on T2WI, and avid enhancement signal intensity on post-contrast T1. Electroencephalogram showed inter-ictal epileptiform activities derived from the right fronto -central lobe. Surgical en bloc resection with a margin of normal bone and cranioplasty were performed. Histopathology showed features indicative of fibrous dysplasia, including osteoid trabeculae arranged haphazardly in a dense fibroblastic stroma, irregular trabeculae lacking conspicuous osteoblastic rimming, and intervening fibrous stroma containing cytologically bland spindle cells. The patient achieved seizure control and has remained neurologically intact. Conclusions: This report has highlighted the importance of early diagnosis of fibrous dysplasia of bone to exclude primary bone malignancy or bone metastasis, to ensure rapid management and symptom control.
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页数:8
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