Research advances in huntingtin-associated protein 1 and its application prospects in diseases

被引：2
|
作者：
Wu, Yongjiang [1 ]
Wang, Yanfei [1 ]
Lu, Yunchi [1 ]
Yan, Junguo [1 ]
Zhao, Hongjun [1 ]
Yang, Riyun [1 ]
Pan, Jingying [1 ]
机构：
[1] Nantong Univ, Med Sch, Dept Histol & Embryol, Nantong, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2024年 / 18卷
基金：
中国国家自然科学基金;
关键词：
huntingtin-associated protein 1; neurological diseases; cancer; diabetes mellitus; neuropathology; TUBEROUS SCLEROSIS COMPLEX; HIPPOCAMPAL NEUROGENESIS; MUTANT HUNTINGTIN; AXONAL-TRANSPORT; INTRACELLULAR TRAFFICKING; EXPANDED POLYGLUTAMINE; TARGETED DISRUPTION; VESICULAR TRANSPORT; BINDING PROTEIN; HAP1; INTERACTS;
D O I：
10.3389/fnins.2024.1402996
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington's disease, Alzheimer's disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.
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页数：15
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