A biocompatible Horner-Wadsworth-Emmons(HWE) reaction triggered by a bioorthogonal proximity-induced platform

被引：0

作者：

Yayue Wang ^{[1
]}

Haojie Yang ^{[1
]}

Jie Li ^{[1
]}

Qiao Kong ^{[2
]}

Siming Zhou ^{[2
]}

Hongbao Sun ^{[1
]}

Lili Pan ^{[3
]}

Qiyong Gong ^{[1
,4
]}

Ping Feng ^{[5
,6
]}

Haoxing Wu ^{[1
,2
]}

机构：

[1] Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Frontiers Science Center for Disease Related Molecular Network, West China Hospital, Sichuan University

[2] Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan University

[3] Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University

[4] Reseacrch Unit of Psychoradiology, Chinese Academy of Medical Sciences

[5] Department of Pharmacy, West China Hospital, Sichuan University

[6] Clinical Trial Center and National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan

来源：

ChineseChemicalLetters | 2024年 / 35卷 / 08期

关键词：

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Here, we present a novel bioorthogonal platform that enables precise positioning of attached moieties in close proximity, thereby facilitating the discovery and optimization of biocompatible reactions. Using this platform, we achieve a Horner-Wadsworth-Emmons(HWE) reaction under physiological conditions,generating a fluorophore in situ with a yield of up to 93%. This proximity platform should facilitate the discovery of various types of biocompatible reactions, making it a versatile tool for biomedical applications.

引用

页码：244 / 247

页数：4

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