Epigenetic changes in colorectal cancer

被引：0
|
作者：
Yan Jia [1 ,2 ]
Mingzhou Guo [1 ]
机构：
[1] Department of Gastroenterology & Hepatology,Chinese PLA General Hospital
[2] Medical College of Nankai
来源：
Chinese Journal of Cancer | 2013年 / 32卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R735.3 [肠肿瘤];
学科分类号：
摘要：
Epigenetic changes frequently occur in human colorectal cancer.Genomic global hypomethylation,gene promoter region hypermethylation,histone modifications,and alteration of miRNA patterns are major epigenetic changes in colorectal cancer.Loss of imprinting(LOI) is associated with colorectal neoplasia.Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation.HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment.Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer.This review is mainly focused on DNA methylation,histone modification,and microRNA changes in colorectal cancer.
引用
收藏
页码：21 / 30
页数：10
相关论文
共 50 条
  • [21] Genomic and Epigenetic Instability in Colorectal Cancer
    Safaei, Akram
    Sobhi, Sara
    Rezaei-Tavirani, Mostafa
    Zali, Mohammad Reza
    IRANIAN JOURNAL OF CANCER PREVENTION, 2013, 6 : 54 - 63
  • [22] Genetic and epigenetic contributions to colorectal cancer
    Dumont, N
    APMIS, 1999, 107 (08) : 711 - 722
  • [23] Epigenetic gender differences in colorectal cancer
    Toth, R.
    Habermann, N.
    Scherer, D.
    Gigic, B.
    Schrotz-King, P.
    Staffa, J.
    Ulrich, A.
    Herpel, E.
    Brenner, H.
    Ulrich, C. M.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : S237 - S237
  • [24] Epigenetic biomarkers of chemoresistance in colorectal cancer
    Moutinho, Catia
    Martinez-Cardus, Anna
    Martinez-Balibrea, Eva
    Abad, Albert
    Esteller, Mane
    CANCER RESEARCH, 2012, 72
  • [25] Colorectal cancer: The epigenetic role of microbiome
    Sabit, Hussein
    Cevik, Emre
    Tombuloglu, Huseyin
    WORLD JOURNAL OF CLINICAL CASES, 2019, 7 (22) : 3683 - 3697
  • [26] Colorectal cancer: a model for epigenetic tumorigenesis
    Wong, J. J. L.
    Hawkins, N. J.
    Ward, R. L.
    GUT, 2007, 56 (01) : 140 - 148
  • [27] Genetic and epigenetic alterations of colorectal cancer
    Hong, Sung Noh
    INTESTINAL RESEARCH, 2018, 16 (03) : 327 - 337
  • [28] Deciphering the epigenetic network in colorectal cancer
    Dominguez, Gemma
    JOURNAL OF PATHOLOGY, 2013, 229 (01): : 1 - 3
  • [29] Epigenetic biomarkers in colorectal cancer diagnostics
    Rawson, James B.
    Bapat, Bharati
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2012, 12 (05) : 499 - 509
  • [30] EPIGENETIC CHANGES IN BREAST CANCER AND OVARIAN CANCER PART I MECHANISMS OF EPIGENETIC CHANGES
    Nowak, Ewa
    Wasinska, Magdalena
    Bednarek, Ilona
    POSTEPY BIOLOGII KOMORKI, 2017, 44 (03) : 301 - 312
12345