The relationship between umbilical cord blood IL-22 level and infantile eczema at 42 days

被引:0
|
作者
Lu, Xujun [1 ]
Wang, Wenge [1 ]
Wang, Yang [2 ]
Huan, Chuo [1 ]
Yang, Yue [1 ]
机构
[1] Air Force Med Univ, Air Force Med Ctr, Dept Pediat, PLA, Beijing, Peoples R China
[2] Wanshou Rd Community Hlth Serv Ctr, Dept Prevent Med, Beijing, Peoples R China
来源
FRONTIERS IN PEDIATRICS | 2024年 / 12卷
关键词
interleukin-22; cord blood; infants; eczema; influence factors;
D O I
10.3389/fped.2024.1376706
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background The occurrence of eczema is related to helper T 22 (Th22) cytokine disorder, and Th22 mainly secretes interleukin-22 (IL-22). This study aims to investigate the predictive value of umbilical cord blood IL-22 levels on the onset of eczema in infants within 42 days. Study design The study selected 157 full-term healthy neonates born between September 2020 and May 2021. Cord blood was collected immediately after birth to determine IL-22 levels, and the infants were followed up for 42 days to assess the incidence of eczema. Results Among the 157 infants who completed the 42-day follow-up, 86 developed eczema and 71 did not. The level of IL-22 in the umbilical cord blood of the eczema group was lower than that of the non-eczema group (p < 0.05). Additionally, the incidence of eczema in children whose Family history of allergy was significantly higher than in the group without eczema (p < 0.05). Logistic regression analysis indicated that low cord blood IL-22 levels and a family history of allergies were independent risk factors for eczema (p < 0.05). The ROC curve of cord blood IL-22 levels and infant eczema showed that the cut-off value is 36.362 pg/ml, the area under the curve (AUC) is 0.613, the standard error is 0.045, the 95% CI is 0.526-0.701, the sensitivity is 63.4%, and the specificity is 57.0%. Therefore, there is a certain correlation between cord blood IL-22 levels and the incidence of infant eczema. Conclusions Low IL-22 levels in umbilical cord blood may be linked to the development of infant eczema within 42 days, indicating a potential predictive value, although this value appears to be limited.
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页数:6
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