Synthesized pyrrole ester ameliorates adjuvant-induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro-inflammatory cytokines

被引:1
|
作者
Kimariyo, Patrick Francis [1 ,3 ]
Kurati, Sony Priya [1 ]
Bhargavi, Samireddi Naga Venkata Durga [1 ]
Gordon, Andrew [2 ]
Kayabu, Dickson [1 ]
Muthyala, Murali Krishna Kumar [1 ]
机构
[1] Andhra Univ, AU Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India
[2] Accra Tech Univ, Sci Lab Technol Dept, Accra, Ghana
[3] Dar es Salaam Inst Technol DIT, Sci & Lab Technol Dept, Dar Es Salaam, Tanzania
关键词
Rheumatoid arthritis; Pyrrole ester; CFA model; Ant-rheumatoid; Rheumatic disease; RHEUMATOID-ARTHRITIS; ANTIARTHRITIC ACTIVITY; MODEL;
D O I
10.1007/s10787-024-01470-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Piperine is an amide alkaloid responsible for producing the pungent smell that comes from black pepper. Piperine has been explained to exhibit significant properties such as anti-rheumatic, anti-inflammatory, and antihypertensive effects. The aim of the study was to synthesize pyrrole ester from piperine and evaluate its anti-arthritis effects in adjuvant-induced arthritis female Wistar rats. In this study, pyrrole ester (AU-5) was designed, synthesized and evaluated for ant-arthritic activity in adjuvant-induced arthritis Wistar rats. The synthesized pyrrole ester (AU-5) was administered in three selected doses (20, 10 and 5 mg/kg) to the arthritic-induced model. The administered ester significantly inhibited the increase in arthritis index, paw and ankle joint swelling compared to the arthritic control group. Similarly, the treated rats exhibited a remarkable increase in body weight increase, improved haematological, biochemical, histopathological and radiological parameters. Moreover, the excess production of rheumatoid factor (RF), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) was noticeably attenuated in all AU-5-treated rats. However, the spleen index, tumour necrosis factor (TNF-alpha) and interleukin-6 (IL-6) were distinctly lowered compared to arthritic control rats. Moreover, AU-5 showed promising liver protection by lowering the level of liver function markers Serum glutamic pyruvic transaminase (SGPT), Serum glutamic-oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) in serum. Henceforth, it might be concluded that AU-5 has an anti-arthritic effect which can be credited to the down regulation of inflammatory markers and the pro-inflammatory cytokines.
引用
收藏
页码:2361 / 2375
页数:15
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