TIM-3 inhibitors: a promising strategy for tumor immunotherapy

被引：1

作者：

Lu, Lu ^{[1
]}

Deng, Liufu ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Frontiers Sci Ctr DrugTarget Identificat, Sch Pharmaceut Sci, Natl Key Lab Innovat Immunotherapy, Shanghai 200240, Peoples R China

来源：

TRENDS IN MOLECULAR MEDICINE | 2024年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.molmed.2024.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ma et al. recently reported a systematic screening of small -molecule compounds targeting the FG-CC' cleft of T cell immunoglobulin and mucin-containing molecule 3 (TIM3). They identified a functional Tim3 inhibitor, ML -T7, that, as a single agent or in combination with antiPD -1, demonstrated strong antitumor activity in preclinical mouse tumor models, supporting its poten

引用

页码：202 / 203

页数：2

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