Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candida glabrata

被引：0
|
作者：
Rahimli, Laman [1 ,2 ,3 ,4 ]
Salmanton-Garcia, Jon [1 ,2 ,3 ,4 ]
Kasper, Philipp [5 ,6 ]
Simon, Michaela [7 ]
Cornely, Oliver A. [1 ,2 ,3 ,4 ,6 ,8 ]
Stemler, Jannik [1 ,2 ,3 ,4 ]
机构：
[1] Univ Cologne, Univ Hosp Cologne, Inst Translat Res, Fac Med,Cologne Excellence Cluster Cellular Stress, Cologne, Germany
[2] Univ Cologne, Univ Hosp Cologne, Fac Med, Ctr Integrated Oncol Aachen Bonn Cologne Duesseldo, Cologne, Germany
[3] Univ Cologne, Univ Hosp Cologne, Fac Med, Excellence Ctr Med Mycol ECMM, Cologne, Germany
[4] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, Cologne, Germany
[5] Univ Cologne, Fac Med, Dept Gastroenterol & Hepatol, Cologne, Germany
[6] Univ Cologne, Univ Hosp Cologne, Cologne, Germany
[7] Univ Cologne, Univ Hosp Cologne, Inst Med Microbiol Immunol & Hyg, Fac Med, D-50937 Cologne, Germany
[8] Univ Cologne, Fac Med, Clin Trials Ctr Cologne ZKS Koln, Cologne, Germany
来源：
MEDICAL MYCOLOGY CASE REPORTS | 2024年 / 43卷
关键词：
Candida albicans; Candida glabrata; Echinocandin-resistance; Necrotizing pancreatitis; Critical care; RISK; GUIDELINES; MANAGEMENT;
D O I：
10.1016/j.mmcr.2024.100636
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We report on a 64-year-old man with necrotizing pancreatitis related, invasive candidiasis, and candidemia. Despite a multidisciplinary management including antifungal therapy, endoscopic interventions and surgery, the patients' infection progressed and lead to colon perforation, retroperitoneal abscess formation, and polymicrobial bloodstream infections. Resistance to echinocandins in Candida glabrata further complicated the course. This report emphasizes the need for vigilant monitoring and exploring alternative therapeutic approaches for patients in critical conditions.
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页数：5
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