Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

被引：44
|
作者：
Coste, A. T. [1 ,2 ]
Kritikos, A. [2 ,3 ]
Li, J. [1 ,2 ,3 ]
Khanna, N. [4 ,5 ,6 ]
Goldenberger, D. [6 ,7 ]
Garzoni, C. [8 ]
Zehnder, C. [9 ]
Boggian, K. [10 ,11 ]
Neofytos, D. [12 ]
Riat, A. [13 ]
Bachmann, D. [1 ,2 ]
Sanglard, D. [1 ,2 ]
Lamoth, F. [1 ,2 ,3 ]
机构：
[1] Lausanne Univ Hosp, Inst Microbiol, Lausanne, Switzerland
[2] Univ Lausanne, Rue Bugnon 46, CH-1011 Lausanne, Switzerland
[3] Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Serv Infect Dis, Rue Bugnon 46, CH-1011 Lausanne, Switzerland
[4] Univ Basel, Div Infect Dis, Basel, Switzerland
[5] Univ Basel, Hosp Epidemiol, Basel, Switzerland
[6] Univ Hosp Basel, Basel, Switzerland
[7] Univ Basel, Div Clin Bacteriol & Mycol, Basel, Switzerland
[8] Clin Luganese Moncucco, Lugano, Switzerland
[9] SYNLAB Suisse SA, Bioggio, Switzerland
[10] Kantonsspital St Gallen, Div Infect Dis, St Gallen, Switzerland
[11] Kantonsspital St Gallen, Hosp Epidemiol, St Gallen, Switzerland
[12] Geneva Univ Hosp, Serv Infect Dis, Geneva, Switzerland
[13] Geneva Univ Hosp, Serv Lab Med, Geneva, Switzerland
来源：
INFECTION | 2020年 / 48卷 / 05期
关键词：
FKS MUTATIONS; CASPOFUNGIN; BREAKPOINTS; SPP;
D O I：
10.1007/s15010-020-01475-8
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance amongCandidaspp. is mainly due to acquiredFKSmutations. In this study, we report the emergence ofFKS-mutantCandida albicans/glabratain Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.
引用
收藏
页码：761 / 766
页数：6
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