Optimization of Preparation Process for Lycopene-Loaded Nanostructured Lipid Carrier by Central Composite Design-Response Surface Methodology

被引：0
|
作者：
Ma, Yongqiang [1 ]
Xiu, Weiye [1 ]
Li, Chenchen [1 ]
Wang, Yiqi [1 ]
Chen, Junjie [1 ]
机构：
[1] College of Food Engineering, Harbin University of Commerce, Harbin,150076, China
来源：
Shipin Kexue/Food Science | 2021年 / 42卷 / 03期
关键词：
Carotenoids - Efficiency - Biochemistry - Surface properties - Particle size;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lycopene is a functional fat-soluble carotenoid, its poor stability limits its bioavailability in food.The preparation of lycopene-loaded nanostructured lipid carriers by the ethanol injection-sonication method was optimized by central composite design combined with response surface methodology.The results showed that lycopene-loaded nanostructured lipid carriers were prepared as a pink suspension under the optimized conditions, with encapsulation efficiency of(90.84 ± 0.41)% and drug loading rate of (2.56 ± 0.01)%.The particle diameter of the product was (126.48 ± 3.87) nm, and polydispersity index 0.188 ± 0.028, and zeta potential (-48.53 ± 2.40) mV.After storage at 4℃ for 30 days, the encapsulation efficiency of lycopene was (84.49 ± 0.44)%, and particle diameter (135.48 ± 7.31) nm, indicating that the nanostructured lipid carriers can improve the stability of lycopene. © 2021, China Food Publishing Company. All right reserved.
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页码：121 / 127
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