Immune-checkpoint blockade protects aged mice from infection

被引：0
|
作者：
Thiele, Daniel [1 ,2 ]
La Gruta, Nicole L. [1 ,2 ]
机构：
[1] Monash Univ, Immun Program, Clayton, Vic, Australia
[2] Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Clayton, Vic, Australia
来源：
NATURE AGING | 2024年 / 4卷 / 07期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
SENESCENCE;
D O I：
10.1038/s43587-024-00664-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A study demonstrates the efficacy of immune-checkpoint blockade in prolonging survival and boosting CD8+ T cell function in aged mice after pathogen exposure. These findings highlight how aging-related immune changes may lead to augmented CD8+ T cell responses to checkpoint blockade, which results in improved protection from infection. The findings also highlight the importance of understanding immune aging in future efforts to target immunotherapies to older adults.
引用
收藏
页码：907 / 908
页数：2
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