Human skeletal muscle aging atlas

被引：21

作者：

Kedlian, Veronika R. ^{[1
]}

Wang, Yaning ^{[2
,3
]}

Liu, Tianliang ^{[2
,3
]}

Chen, Xiaoping ^{[2
]}

Bolt, Liam ^{[1
]}

Tudor, Catherine ^{[1
]}

Shen, Zhuojian ^{[4
]}

Fasouli, Eirini S. ^{[1
]}

Prigmore, Elena ^{[1
]}

Kleshchevnikov, Vitalii ^{[1
]}

Pett, Jan Patrick ^{[1
]}

Li, Tong ^{[1
]}

Lawrence, John E. G. ^{[1
]}

Perera, Shani ^{[1
]}

Prete, Martin ^{[1
]}

Huang, Ni ^{[1
]}

Guo, Qin ^{[2
]}

Zeng, Xinrui ^{[2
,3
]}

Yang, Lu ^{[1
]}

Polanski, Krzysztof ^{[1
]}

Chipampe, Nana-Jane ^{[1
]}

Dabrowska, Monika ^{[1
]}

Li, Xiaobo ^{[5
]}

Bayraktar, Omer Ali ^{[1
]}

Patel, Minal ^{[1
]}

Kumasaka, Natsuhiko ^{[1
]}

Mahbubani, Krishnaa T. ^{[6
,7
]}

Xiang, Andy Peng ^{[2
]}

Meyer, Kerstin B. ^{[1
]}

Saeb-Parsy, Kourosh ^{[6
,7
]}

Teichmann, Sarah A. ^{[1
,8
]}

Zhang, Hongbo ^{[2
,3
]}

机构：

[1] Wellcome Genome Campus, Wellcome Sanger Inst, Cambridge, England

[2] Sun Yat Sen Univ, Zhongshan Sch Med, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Zhongshan Sch Med, Adv Med Technol Ctr, Guangzhou, Peoples R China

[4] Sun Yat sen Univ, Sun Yat sen Mem Hosp, Dept Thorac Surg, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Peoples R China

[5] Sun Yat Sen Univ, Core Facil Med Sci, Guangzhou, Peoples R China

[6] Univ Cambridge, Dept Surg, Cambridge, England

[7] NIHR Cambridge Biomed Res Ctr, Collaborat Biorepository Translat Med CBTM, Cambridge, England

[8] Univ Cambridge, Cavendish Lab, Cambridge, England

来源：

NATURE AGING | 2024年 / 4卷 / 05期

基金：

英国惠康基金; 中国国家自然科学基金;

关键词：

SINGLE-CELL ANALYSIS; ACTIVATION; MECHANISMS; FOLLICULIN; EXPRESSION; CYTOKINES; MASS;

D O I：

10.1038/s43587-024-00613-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes. Our atlas also highlights an expansion of nuclei associated with the neuromuscular junction, which may reflect re-innervation, and outlines how the loss of fast-twitch myofibers is mitigated through regeneration and upregulation of fast-type markers in slow-twitch myofibers with age. Furthermore, we document the function of aging muscle microenvironment in immune cell attraction. Overall, we present a comprehensive human skeletal muscle aging resource (https://www.muscleageingcellatlas.org/) together with an in-house mouse muscle atlas to study common features of muscle aging across species. The Muscle Aging Cell Atlas presents approximately 200,000 single-cell and single-nuclei transcriptomes from 17 human donors across different ages, uncovering mechanisms of aging in muscle stem cells, myofibers and microenvironment cells, and demonstrates parallels in mouse muscle aging.

引用

页码：727 / 744

页数：35

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