CSDE1: a versatile regulator of gene expression in cancer

被引：3
|
作者：
Ciocia, Annagiulia [1 ,2 ]
Mestre-Farras, Neus [1 ]
Vicent-Nacht, Ignacio [1 ,2 ]
Guitart, Tanit [1 ]
Gebauer, Fatima [1 ,2 ]
机构：
[1] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Dr Aiguader 88, Barcelona 08003, Spain
[2] Univ Pompeu Fabra UPF, Dr Aiguader 88, Barcelona, Spain
来源：
NAR CANCER | 2024年 / 6卷 / 02期
关键词：
RNA-BINDING PROTEINS; RIBOSOME ENTRY SEGMENT; POLY(A)-BINDING PROTEIN; UNR; TRANSLATION; ROLES; DIFFERENTIATION; INITIATION; UPSTREAM; TURNOVER;
D O I：
10.1093/narcan/zcae014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug development, particularly in the context of RNA-binding modulators of translation. This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss context-specific functions of CSDE1 in tumor development, its mechanisms of action, and highlight features that support its role as a molecular adaptor. Additionally, we discuss the regulation of CSDE1 itself and its potential value as biomarker and therapeutic target. Graphical Abstract
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页数：10
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