Correlation of Thyroid Stimulating hormone and Liver function test in Hypothyroid and Euthyroid subjects

The thyroid hormones play an important role in basal metabolic rate, and the liver is important in the metabolism of thyroid hormones, so, these two organs affect functioning of one another. The proper evaluation of hepatic functions (LFTs) in patients with thyroid disorders might be of clinical relevance for undertaking preventive and therapeutic strategies. The study was designed as hospital-based retrospective cross-sectional study conducted in Central Clinical Laboratory of Adesh Institute of Medical Sciences and Research, (AIMSR) Bathinda, a tertiary care teaching hospital in Punjab, India, from a period of Jan 2022 to Dec 2023. Cases included 100 newly diagnosed hypothyroid patients not undergoing any treatment for thyroid dysfunction and controls consisted of 100 euthyroid subjects. Levels of thyroid stimulating hormone (TSH) in cases were significantly high as compared to the controls (r=0.268, p=0.03). Levels of aspartate aminotransferase (AST) (r=0.352, p=0.003) and alanine aminotransferase (ALT) (r=0.27, p=0.006) were also significantly high in cases as compared to controls. Comparison of TSH levels in cases with various liver function tests (LFTs) depicted significant correlation with AST (r=0.334, p=0.001) and ALT (r= 0,399, p=0.001). This study is significantly important for consideration of liver injury due to hypothyroidism. Early detection and treatment can prevent further complications and would be helpful during management of hypothyroid patients.