Pharmacological interventions in human aging

被引：2

作者：

Petr, Michael Angelo ^{[1
]}

Matiyevskaya, Frida ^{[1
]}

Osborne, Brenna ^{[1
]}

Berglind, Magnus ^{[1
]}

Reves, Simon ^{[1
]}

Zhang, Bin ^{[1
]}

Ben Ezra, Michael ^{[1
]}

Carmona-Marin, Lina Maria ^{[1
]}

Syadzha, Muhammad Farraz ^{[1
]}

Mediavilla, Marta Cortes ^{[1
]}

Keijzers, Guido ^{[1
]}

Bakula, Daniela ^{[1
]}

Mkrtchyan, Garik, V ^{[1
]}

Scheibye-Knudsen, Morten ^{[1
]}

机构：

[1] Univ Copenhagen, Ctr Hlth Aging, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark

来源：

AGEING RESEARCH REVIEWS | 2024年 / 95卷

关键词：

Aging; Clinical trials; Pharmacological interventions; Database; Small molecules; Age -associated diseases; ALL-CAUSE MORTALITY; NICOTINAMIDE RIBOSIDE; CALORIC RESTRICTION; LIFE-SPAN; SKELETAL-MUSCLE; OLDER-ADULTS; METFORMIN; MITOCHONDRIAL; RAPAMYCIN; RECEPTOR;

D O I：

10.1016/j.arr.2024.102213

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pharmacological interventions are emerging as potential avenues of alleviating age-related disease. However, the knowledge of ongoing clinical trials as they relate to aging and pharmacological interventions is dispersed across a variety of mediums. In this review we summarize 136 age-related clinical trials that have been completed or are ongoing. Furthermore, we establish a database that describe the trials (AgingDB, www.agingdb.com) keeping track of the previous and ongoing clinical trials, alongside their outcomes. The aim of this review and database is to give people the ability to easily query for their trial of interest and stay up to date on the latest results. In sum, herein we give an overview of the current pharmacological strategies that have been applied to target human aging.

引用

页数：14

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