Antibiotics-associated pseudomembranous colitis: a disproportionality analysis of the US food and drug administration adverse event reporting system (FAERS) database

被引：0
|
作者：
Chen, Jinhua [1 ,2 ]
Yu, Weijiang [1 ,2 ]
Zhang, Wancun [3 ]
Sun, Cuicui [4 ]
Zhang, Wenzhou [1 ,2 ]
机构：
[1] Zhengzhou Univ, Affiliated Canc Hosp, Dept Pharm, Zhengzhou, Peoples R China
[2] Henan Canc Hosp, Henan Engn Res Ctr Tumor Precis Med & Comprehens E, Henan Prov Key Lab Anticanc Drug Res, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Childrens Hosp, Dept Pediat Oncol Surg, Hlth Commiss,Henan Prov Key Lab Precis Diag & Trea, Zhengzhou, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Pharm, Jinan, Peoples R China
来源：
EXPERT OPINION ON DRUG SAFETY | 2024年
关键词：
Pseudomembranous colitis; antibiotic; FAERS; adverse event; disproportionality analyzes; CLOSTRIDIUM-DIFFICILE INFECTION; EPIDEMIOLOGY; DIARRHEA;
D O I：
10.1080/14740338.2024.2341813
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
BackgroundEvaluating antibiotics most commonly associated with pseudomembranous colitis (PMC) based on the real-world data is of great significance.Research design and methodsWe used the data from FAERS to evaluate the potential association between antibiotics and PMC by disproportionality analyzes.ResultsEighty-one antibiotics which met the three algorithms simultaneously were enrolled. There were 1683 reports of PMC associated with the enrolled antibiotics. In the top 24 antibiotics, cefoxitin, streptomycin, fosfomycin, and micafungin had a high risk of PMC, but there were few reports in the literature.ConclusionsThis study was of great significance for healthcare professionals to realize the potential PMC risks of antibiotics.
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页数：7
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