Under the vehicle’ s dynamic loads, the damage from track structure vibration has close ties with track structural parameters. In this paper, by using high-speed vehicle-track-bridge coupled finite-element analytic model, the influences of CRTSII track structural parameters on track structure vibration was analyzed in time-and frequency-domains. The results showed that with the increase of rail mass and rail inertia moment, the wheel-rail interaction force can be reduced, hence using heavy rail can reduce the level of rail vibration and it is meaningful for decreasing wheel-rail noise. The vibration level of rail reduces with the increase of supporting slab stiffness in the frequency range of 1~40 Hz; however, in the range of 40~100 Hz, the vibration level of rail rises with the increase of supporting slab stiffness. In the range of 40~100 Hz, the vibration level of track slab and bridge decreases with the decrease of supporting slab stiffness and the effect of vibration reduction is improved. With the increase of slab thickness in the frequency range of 60~250 Hz, the vibration level of rail decreases and then increases in the frequency range of 2.5~60 Hz. With the increase of track slab thickness in the range of above 60 Hz, the vibration level of track slab decreases; and it increases in the frequency range of 2.5~60 Hz. The vibration level of bridge decreases with the increase of track slab thickness in the range of above 20 Hz. © 2022, Central South University Press. All rights reserved.