Determination of Chlorpheniramine Residues in Foods of Animal and Plant Origin by GC-MS/MS

In this study, an analytical method for the determination of chlorpheniramine residues in foods of animal and plant origin by gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed. The samples were pretreated with a modified quick, easy, cheap, effective, rugged, safe (QuEChERS) method and solid phase extraction, and the analytes were separated on HP-5MS GC column and quantitatively determined by an external standard method. The experimental results showed that the method exhibited a good linear relationship in the range of 0.01-0.5 and 0.03-1 μg/mL with correlation coefficient R2 higher than 0.999 for banana and an animal food sample, respectively. The spiked recoveries for three matrixes were measured to be 80.6%-107.8%, with relative standard deviation (RSD) of 2.3%-8.5%. This method was characterized by simple operation and good reproducibility. It was suitable for batch sample detection, providing a technical basis for evaluating the risk of dietary exposure to chlorpheniramine. © 2021, China Food Publishing Company. All right reserved.