Galactan induces macrophage M0 to M1 conversion to combat colon cancer

被引：2
|
作者：
Meng, Yue [1 ]
Yang, Guang [1 ]
Ren, Ai [1 ]
Qu, Yunhe [1 ]
Wang, Xue [1 ]
Mayo, Kevin H. [2 ]
Zhou, Yifa [1 ]
Song, Chengcheng [1 ]
机构：
[1] Northeast Normal Univ, Engn Res Ctr Glycoconjugates, Sch Life Sci,Minist Educ, Jilin Prov Key Lab Chem & Biol Changbai Mt Nat Dru, Changchun 130024, Peoples R China
[2] Univ Minnesota, Dept Biochem Mol Biol & Biophys, 6-155 Jackson Hall, Minneapolis, MN 55455 USA
来源：
FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2024年 / 30卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cantharellus cibarius; galactan; macrophages; antitumor effect; TUMOR-ASSOCIATED MACROPHAGES; STRUCTURAL-CHARACTERIZATION; IMMUNOMODULATORY ACTIVITY; CELLS; ACTIVATION; MECHANISMS; PHENOTYPE;
D O I：
10.3136/fstr.FSTR-D-23-00039
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow -derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-alpha and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll -like receptor 2 and activation of MAPKs and NF -KB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.
引用
收藏
页码：75 / 82
页数：9
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