IS607 TnpB is a hypercompact RNA-guided DNA endonuclease

被引：0
|
作者：
Yang, Hui [1 ]
Patel, Dinshaw J. [2 ]
机构：
[1] Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Chinese Acad Sci, Ctr Excellence Mol Cell Sci,Key Lab RNA Innovat Sc, Shanghai, Peoples R China
[2] Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA
来源：
CELL RESEARCH | 2024年 / 34卷 / 07期
关键词：
D O I：
10.1038/s41422-024-00973-w
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Zhiwei Huang lab report on a hypercompact IS607 TnpB protein that naturally co-occurs with the conserved RAGATH-18 RNA, thereby identifying a new family of compact RNA-guided DNA endonucleases. Such an IS607 TnpB-based approach for programmable genome editing in both Escher-ichia coli and human cells, combined with its structural and target-adjacent motif divergence from earlier reported IS200/IS605 TnpB systems, highlights the diversity of the non-Cas genome editor toolbox.
引用
收藏
页码：473 / 474
页数：2
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