Measurements of peri-prostatic adipose tissue by MRI predict bone metastasis in patients with newly diagnosed prostate cancer

被引:0
|
作者
Liu, Bo-Hao [1 ]
Mao, Yun-Hua [1 ]
Li, Xiao-Yang [1 ]
Luo, Rui-Xiang [1 ]
Zhu, Wei-An [1 ]
Su, Hua-Bin [1 ]
Zeng, Heng-Da [1 ]
Chen, Chu-Hao [1 ]
Zhao, Xiao [1 ]
Zou, Chen [1 ]
Luo, Yun [1 ,2 ]
机构
[1] Sun Yat sen Univ, Affiliated Hosp 3, Dept Urol, Guangzhou, Peoples R China
[2] Kashgar First Peoples Hosp, Dept Urol, Kashgar, Xinjiang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
基金
中国国家自然科学基金;
关键词
prostate cancer; metastasis; peri-prostatic adipose tissue; nomogram; MRI; RISK STRATIFICATION; FAT; GUIDELINES; SURVIVAL; PATTERNS; PROPOSAL;
D O I
10.3389/fonc.2024.1393650
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: To investigate the role of MRI measurements of peri-prostatic adipose tissue (PPAT) in predicting bone metastasis (BM) in patients with newly diagnosed prostate cancer (PCa). Methods: We performed a retrospective study on 156 patients newly diagnosed with PCa by prostate biopsy between October 2010 and November 2022. Clinicopathologic characteristics were collected. Measurements including PPAT volume and prostate volume were calculated by MRI, and the normalized PPAT (PPAT volume/prostate volume) was computed. Independent predictors of BM were determined by univariate and multivariate logistic regression analysis, and a new nomogram was developed based on the predictors. Receiver operating characteristic (ROC) curves were used to estimate predictive performance. Results: PPAT and normalized PPAT were associated with BM (P<0.001). Normalized PPAT positively correlated with clinical T stage(cT), clinical N stage(cN), and Grading Groups(P<0.05). The results of ROC curves indicated that PPAT and normalized PPAT had promising predictive value for BM with the AUC of 0.684 and 0.775 respectively. Univariate and multivariate analysis revealed that high normalized PPAT, cN, and alkaline phosphatase(ALP) were independently predictors of BM. The nomogram was developed and the concordance index(C-index) was 0.856. Conclusions: Normalized PPAT is an independent predictor for BM among with cN, and ALP. Normalized PPAT may help predict BM in patients with newly diagnosed prostate cancer, thus providing adjunctive information for BM risk stratification and bone scan selection.
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页数:9
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