Five biomarkers from one cerebrospinal fluid sample to stage Alzheimer's disease

被引:1
|
作者
Salvado, Gemma [1 ]
Hansson, Oskar [1 ]
机构
[1] Lund Univ, Lund, Sweden
来源
NATURE AGING | 2024年 / 4卷 / 05期
关键词
TAU;
D O I
10.1038/s43587-024-00618-y
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Staging Alzheimer's disease on the basis of the disease's biological underpinnings might help with stratification and prognostication, both in the clinical setting and in clinical trials. We propose a staging model based on only five biomarkers, which are related to amyloid-beta and tau pathologies in different ways and can be measured with a single sample of cerebrospinal fluid.
引用
收藏
页码:623 / 624
页数:2
相关论文
共 50 条
  • [31] Cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease
    Kolupaeva, E.
    Zhukova, I.
    Zhukova, N.
    Alifirova, V.
    Izhboldina, O.
    Mironova, Y.
    Latypova, A.
    Nikitina, M.
    Titova, M.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 381 : 673 - 673
  • [32] To tap or not to tap: Cerebrospinal fluid biomarkers of Alzheimer's disease
    Growdon, JH
    ANNALS OF NEUROLOGY, 1998, 44 (01) : 6 - 7
  • [33] The Impact of Cerebrospinal Fluid Biomarkers on the Diagnosis of Alzheimer's Disease
    Engelborghs, Sebastiaan
    Le Bastardl, Nathalie
    MOLECULAR DIAGNOSIS & THERAPY, 2012, 16 (03) : 135 - 141
  • [34] Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease
    Skogseth, Ragnhild
    Mulugeta, Ezra
    Ballard, Clive
    Rongve, Arvid
    Nore, Sabine
    Alves, Guido
    Aarsland, Dag
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2008, 25 (06) : 559 - 563
  • [35] Reply: Cerebrospinal fluid proteomics for biomarkers of Alzheimer's disease
    Lee, Kelvin H.
    Relkin, Norman R.
    ANNALS OF NEUROLOGY, 2007, 61 (05) : 497 - 498
  • [36] Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid
    Riekse, Robert G.
    Li, Ge
    Petrie, Eric C.
    Leverenz, James B.
    Vavrek, Darcy
    Vuletic, Simona
    Albers, John J.
    Montine, Thomas J.
    Lee, Virginia M. -Y.
    Lee, Michael
    Seubert, Peter
    Galasko, Douglas
    Schellenberg, Gerard D.
    Hazzard, William R.
    Peskind, Elaine R.
    JOURNAL OF ALZHEIMERS DISEASE, 2006, 10 (04) : 399 - 406
  • [37] Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    Blennow, Kaj
    Hampel, Harald
    Weiner, Michael
    Zetterberg, Henrik
    NATURE REVIEWS NEUROLOGY, 2010, 6 (03) : 131 - 144
  • [38] Cerebrospinal fluid biomarkers in the evaluation of Alzheimer disease
    Verbeek, Marcel M.
    Rikkert, Marcel G. M. Olde
    CLINICAL CHEMISTRY, 2008, 54 (10) : 1589 - 1591
  • [39] Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    Kaj Blennow
    Harald Hampel
    Michael Weiner
    Henrik Zetterberg
    Nature Reviews Neurology, 2010, 6 : 131 - 144
  • [40] Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease
    Irwin, David J.
    Trojanowski, John Q.
    Grossman, Murray
    FRONTIERS IN AGING NEUROSCIENCE, 2013, 5