Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis

被引：2
|
作者：
Chen, Yuting [1 ,2 ]
Guo, Chenchen [2 ]
Cai, Xinlei [3 ,4 ]
Hu, Liang [2 ]
Tong, Xinyuan [2 ]
Xue, Yun [2 ,3 ]
Zhao, Qiqi [2 ,3 ]
Zhang, Tengfei [2 ,4 ]
Chen, Yuan [2 ,4 ]
Fang, Yongting [2 ,4 ]
He, Yayi [5 ]
Li, Yan [6 ,7 ]
Zhou, Bin [1 ,2 ,3 ,4 ]
Ji, Hongbin [1 ,2 ,3 ,4 ]
机构：
[1] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Key Lab Multi Cell Syst, Shanghai, Peoples R China
[3] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310013, Peoples R China
[4] Univ Chinese Acad Sci, Beijing, Peoples R China
[5] Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Med Oncol, Shanghai, Peoples R China
[6] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China
[7] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China
来源：
CELL DISCOVERY | 2024年 / 10卷 / 01期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
CHEMORESISTANCE; HETEROGENEITY;
D O I：
10.1038/s41421-024-00687-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [21] Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer
    Mohammad Aarif Siddiqui
    Paradesi Naidu Gollavilli
    Vignesh Ramesh
    Beatrice Parma
    Annemarie Schwab
    Maria Eleni Vazakidou
    Ramakrishnan Natesan
    Ozge Saatci
    Ida Rapa
    Paolo Bironzo
    Harald Schuhwerk
    Irfan Ahmed Asangani
    Ozgur Sahin
    Marco Volante
    Paolo Ceppi
    British Journal of Cancer, 2021, 124 : 281 - 289
  • [22] Response of non small cell lung cancer xenografts to targeted therapies is not related to epithelial-to-mesenchymal transition
    Rolff, J.
    Lamich, A.
    Fichtner, I.
    EJC SUPPLEMENTS, 2009, 7 (04): : 36 - 37
  • [23] Epithelial-mesenchymal transition and brain metastasis in non-small cell lung cancer
    Goodgame, B. W.
    Young, D. S.
    Haley, J.
    Mark, W.
    Govindan, R.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [24] Immunohistochemical study of the epithelial-to-mesenchymal transition phenotype in nonsmall cell lung cancer
    Rodriguez-Lopez, Xavier Luis
    Perez-Morales, Jaileene
    Santiago-Cardona, Pedro
    FASEB JOURNAL, 2018, 32 (01):
  • [25] How apoptosis and epithelial-to-mesenchymal transition are nested in EGFR inhibitors resistance in lung cancer
    Garinet, Simon
    Didelot, Audrey
    Garelli, Elena
    Pallier, Karine
    Blons, Helene
    Legras, Antoine
    JOURNAL OF THORACIC DISEASE, 2019, 11 (01) : 47 - 49
  • [26] Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically Regulating the Epithelial-to-Mesenchymal Transition (EMT)
    Yun, Yang
    Gao, Rui
    Yue, Huifeng
    Guo, Lin
    Li, Guangke
    Sang, Nan
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 51 (19) : 11401 - 11411
  • [27] Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis
    Qi, Hui-wei
    Xin, Ling-yan
    Xu, Xin
    Ji, Xian-xiu
    Fan, Li-hong
    JOURNAL OF TRANSLATIONAL MEDICINE, 2014, 12
  • [28] Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis
    Hui-wei Qi
    Ling-yan Xin
    Xin Xu
    Xian-xiu Ji
    Li-hong Fan
    Journal of Translational Medicine, 12
  • [29] Transcriptional Profiling Reveals Mesenchymal Subtypes of Small Cell Lung Cancer with Activation of the Epithelial-to-Mesenchymal Transition and Worse Clinical Outcomes
    Cho, Hae Jin
    Hong, Soon Auck
    Ryu, Daeun
    Hong, Sook-Hee
    Kim, Tae-Min
    CANCERS, 2022, 14 (22)
  • [30] An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
    Lobb, Richard J.
    Visan, Kekoolani S.
    Wu, Li-Ying
    Norris, Emma L.
    Hastie, Marcus L.
    Everitt, Sarah
    Yang, Ian A.
    Bowman, Rayleen V.
    Siva, Shankar
    Larsen, Jill E.
    Gorman, Jeffrey J.
    MacManus, Michael
    Leimgruber, Antoine
    Fong, Kwun M.
    Moller, Andreas
    COMMUNICATIONS BIOLOGY, 2023, 6 (01)
12345