Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis

被引:2
|
作者
Chen, Yuting [1 ,2 ]
Guo, Chenchen [2 ]
Cai, Xinlei [3 ,4 ]
Hu, Liang [2 ]
Tong, Xinyuan [2 ]
Xue, Yun [2 ,3 ]
Zhao, Qiqi [2 ,3 ]
Zhang, Tengfei [2 ,4 ]
Chen, Yuan [2 ,4 ]
Fang, Yongting [2 ,4 ]
He, Yayi [5 ]
Li, Yan [6 ,7 ]
Zhou, Bin [1 ,2 ,3 ,4 ]
Ji, Hongbin [1 ,2 ,3 ,4 ]
机构
[1] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Key Lab Multi Cell Syst, Shanghai, Peoples R China
[3] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310013, Peoples R China
[4] Univ Chinese Acad Sci, Beijing, Peoples R China
[5] Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Med Oncol, Shanghai, Peoples R China
[6] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China
[7] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
CHEMORESISTANCE; HETEROGENEITY;
D O I
10.1038/s41421-024-00687-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [1] Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer
    Wang, Biao
    Tang, Zhen
    Gong, Huiyuan
    Zhu, Li
    Liu, Xuegang
    BIOSCIENCE REPORTS, 2017, 37
  • [2] Epithelial-to-mesenchymal transition (EMT) is required for resistance to anti-folate chemotherapy in lung cancer
    Liang, S.
    Marti, T. M.
    Dorn, P.
    Froment, L.
    Hall, S.
    Berezowska, S.
    Kocher, G.
    Schmid, R. A.
    Peng, R.
    JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (04) : S63 - S63
  • [3] Effect of AXL on the epithelial-to-mesenchymal transition in non-small cell lung cancer
    Ying, Xueming
    Chen, Jun
    Huang, Xueming
    Huang, Peng
    Yan, Shaocong
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (01) : 785 - 790
  • [4] Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
    Nurwidya, Fariz
    Takahashi, Fumiyuki
    Murakami, Akiko
    Takahashi, Kazuhisa
    CANCER RESEARCH AND TREATMENT, 2012, 44 (03): : 151 - 156
  • [5] Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer
    Legras, Antoine
    Pecuchet, Nicolas
    Imbeaud, Sandrine
    Pallier, Karine
    Didelot, Audrey
    Roussel, Helene
    Gibault, Laure
    Fabre, Elizabeth
    Le Pimpec-Barthes, Francoise
    Laurent-Puig, Pierre
    Blons, Helene
    CANCERS, 2017, 9 (08):
  • [6] Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis
    Wang, Yan
    Shang, Yongfeng
    EXPERIMENTAL CELL RESEARCH, 2013, 319 (02) : 160 - 169
  • [7] Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer
    S-Q Liang
    T M Marti
    P Dorn
    L Froment
    S R R Hall
    S Berezowska
    G Kocher
    R A Schmid
    R-W Peng
    Cell Death & Disease, 2015, 6 : e1824 - e1824
  • [8] Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer
    Liang, S-Q
    Marti, T. M.
    Dorn, P.
    Froment, L.
    Hall, S. R. R.
    Berezowska, S.
    Kocher, G.
    Schmid, R. A.
    Peng, R-W
    CELL DEATH & DISEASE, 2015, 6 : e1824 - e1824
  • [9] Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
    Celia-Terrassa, Toni
    Jolly, Mohit Kumar
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020, 10 (07): : 1 - 17
  • [10] Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer
    Canadas, Israel
    Rojo, Federico
    Taus, Alvaro
    Arpi, Oriol
    Arumi-Uria, Montserrat
    Pijuan, Lara
    Menendez, Silvia
    Zazo, Sandra
    Domine, Manuel
    Salido, Marta
    Mojal, Sergi
    Garcia de Herreros, Antonio
    Rovira, Ana
    Albanell, Joan
    Arriola, Edurne
    CLINICAL CANCER RESEARCH, 2014, 20 (04) : 938 - 950