A study on antibacterial and anti-inflammatory activity of xylitol-based polymeric nano-bioactive glass nanocomposites

Bioactive glasses have been shown effective in promoting bone healing by interacting with the body, gradual degradation, and supporting new bone growth. They present a promising option for therapies aimed at regenerating bone tissue. In this study, we developed a novel material, PXMA/n-BG, by combining xylitol, maleic acid, and adipic acid, and incorporating nano-bioactive glass, all synthesized without the use of a catalyst. The sol-gel method was used to fabricate the n-BG (SiO2-CaO-P2O5). The incorporation of n-BG into the polymer was found to enhance its biocompatibility and effectiveness for orthopedic applications. The synthesized polymer and its nanocomposite were characterized by FTIR, 1H NMR, 13C NMR, DSC, GPC, UTM, XRD and HR-SEM. X-ray diffraction and high-resolution scanning electron microscopy are utilized to investigate the structure and surface of the n-BG and polymeric composite material. The strength and flexibility of a plastic material with tiny particles mixed in were tested using a universal testing machine. We examined the elemental composition and thermal stability of n-BG through specialized testing like energy-dispersive X-ray analysis (EDX) and thermogravimetric analysis (TGA). The research focused on the potential of xylitol-based polymer and its nanocomposite to inhibit the growth of harmful bacteria in food. We conducted experiments to determine the efficacy of the antibacterial substance against various bacteria strains. The antibacterial potential of the extracts was assessed by the agar diffusion method using MHA plate. Furthermore, we investigated the ability of the material and its nanoparticles to reduce inflammation.