Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

被引：3

作者：

Jafarinia, Hamidreza ^{[1
]}

Khalilimeybodi, Ali ^{[2
]}

Barrasa-Fano, Jorge ^{[3
]}

Fraley, Stephanie I. ^{[4
]}

Rangamani, Padmini ^{[2
]}

Carlier, Aurelie ^{[1
]}

机构：

[1] Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Cell Biol Inspired Tissue Engn, Maastricht, Netherlands

[2] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA

[3] Katholieke Univ Leuven, Dept Mech Engn, Biomech Sect, Leuven, Belgium

[4] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

NPJ SYSTEMS BIOLOGY AND APPLICATIONS | 2024年 / 10卷 / 01期

关键词：

FOCAL ADHESION KINASE; HIPPO PATHWAY; FORCE TRANSMISSION; LIGAND-BINDING; E-CADHERIN; YAP; TRACTION; ACTIVATION; LOCALIZATION; COMPLEX;

D O I：

10.1038/s41540-024-00414-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.

引用

页数：14

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