Design and Synthesis of Novel 1,4-Dihydropyridine Derivatives as Antioxidant and Antimicrobial Agents

被引：0

作者：

Chavan, Prabhakar ^{[1
]}

Hanamshetty, Prashant C. ^{[2
]}

Biradar, Balaji ^{[3
]}

Nagabhushan, M. M. ^{[4
]}

机构：

[1] Kuvempu Univ, Sahyadri Sci Coll, Dept PG Studies & Res Chem, Shivamogga 577203, Karnataka, India

[2] Guru Nanak First Grade Coll, Dept Chem, Bidar 585403, India

[3] Chanabasaveshawar Gurukul Sci Degree Coll, Dept Phys, Tawad 585413, K, India

[4] Govt Engn Coll, Dept Chem Engn, Raichur, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 05期

关键词：

synthesis; MCQRs; 1,4-dihydropyridine; antioxidant; antimicrobial; CHANNEL;

D O I：

10.1134/S1070428024050130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4 Dihydropyridines are one of the most used scaffolds in drug development. The present paper describes the autocatalytic four-component reactions of heterocyclic aldehydes, malononitrile, and piperidine, leading to novel 2-amino-1,4-dihydro-6-[pyridin-1(4H)-yl]-4-(hetero-2/3-yl)pyridine-3,5-dicarbonitrile derivatives in good yields. The structure of the synthesized compounds was confirmed by IR and H-1 and C-13 NMR and mass spectrometry. 4-(1H-Indol-3-yl)-substituted 1,4-dihydropyridine exhibited good radical scavenging activity, while its thiophen-2-yl-substituted analog proved to be potent antimicrobial agent.

引用

页码：912 / 917

页数：6

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