Temperature-Controlled Divergent Synthesis of Pyrazoles and 1-Tosyl-1H-pyrazoles under Transition-Metal-Catalyst- and Oxidant-Free Conditions

被引：0

作者：

Wang, Kai ^{[1
,2
]}

Xu, Wenjing ^{[1
,2
]}

Xia, Chengcai ^{[3
]}

Cao, Xianting ^{[1
,2
]}

机构：

[1] Jining Med Univ, Coll Med Engn, Jining 272067, Peoples R China

[2] Jining Med Univ, Key Lab Med Funct Nanomat, Jining 272067, Peoples R China

[3] Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Inst Pharmacol, Jinan 271016, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 08期

关键词：

temperature-controlled; ionic liquids; divergent synthesis; pyrazole derivatives; green strategies; DERIVATIVES; POTENT; SELECTIVITY; CYCLIZATION; INHIBITORS; EFFICIENT; AFFINITY; CAPTURE;

D O I：

10.3390/molecules29081706

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed. The desired products were obtained in moderate to excellent yields from common starting materials in both ionic liquids and ethanol by simply tuning the reaction temperature. This strategy employs easily synthesized substrates, mild reaction conditions, and excellent functional-group tolerance.

引用

页数：13

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