Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency

被引：0

作者：

Alshareef, F. M. ^{[1
]}

Alamshany, Zahra M. ^{[1
]}

Al-Harbi, Sami A. ^{[2
]}

Allehyani, Esam S. ^{[2
]}

Ibrahim, Magdy A. ^{[3
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia

[2] Univ Coll Al Jamoum, Umm Al Qura Univ, Dept Chem, Mecca, Saudi Arabia

[3] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11757, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 10期

关键词：

6,8-Dimethylchromone-3-carbonitrile; heteroannulation; chromenopyridothiadiazolopyrimidines; chromenopyridopyrimidothiadiazines; CHROMONES;

D O I：

10.1080/00397911.2024.2346565

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions 4 was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (1). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor 4 with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound 4 with some alpha-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds 7, 12 and 14. The synthesized products were inferred using analytical and spectral data. [GRAPHICS] .

引用

页码：843 / 852

页数：10

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