Chronotype and subjective sleep quality predict white matter integrity in young people with emerging mental disorders

被引:0
|
作者
Crouse, Jacob J. [1 ]
Park, Shin Ho [1 ]
Hermens, Daniel F. [2 ]
Lagopoulos, Jim [2 ]
Park, Minji [1 ]
Shin, Mirim [1 ]
Carpenter, Joanne S. [1 ]
Scott, Elizabeth M. [1 ]
Hickie, Ian B. [1 ]
机构
[1] Univ Sydney, Brain & Mind Ctr, 94-100 Mallett St, Sydney, NSW, Australia
[2] Univ Sunshine Coast, Thompson Inst, Sunshine Coast, Qld, Australia
基金
澳大利亚国家健康与医学研究理事会; 芬兰科学院; 英国医学研究理事会;
关键词
bipolar disorder; depression; endophenotype; imaging; prediction; youth mental health; PSYCHOMETRIC EVALUATION; HEALTH-SERVICES; OBJECTIVE SLEEP; SEX-DIFFERENCES; ADOLESCENCE; MULTISITE; WAKE; MICROSTRUCTURE; TRACTOGRAPHY; DISCREPANCY;
D O I
10.1111/ejn.16351
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Protecting brain health is a goal of early intervention. We explored whether sleep quality or chronotype could predict white matter (WM) integrity in emerging mental disorders. Young people (N = 364) accessing early-intervention clinics underwent assessments for chronotype, subjective sleep quality, and diffusion tensor imaging. Using machine learning, we examined whether chronotype or sleep quality (alongside diagnostic and demographic factors) could predict four measures of WM integrity: fractional anisotropy (FA), and radial, axial, and mean diffusivities (RD, AD and MD). We prioritised tracts that showed a univariate association with sleep quality or chronotype and considered predictors identified by >= 80% of machine learning (ML) models as 'important'. The most important predictors of WM integrity were demographics (age, sex and education) and diagnosis (depressive and bipolar disorders). Subjective sleep quality only predicted FA in the perihippocampal cingulum tract, whereas chronotype had limited predictive importance for WM integrity. To further examine links with mood disorders, we conducted a subgroup analysis. In youth with depressive and bipolar disorders, chronotype emerged as an important (often top-ranking) feature, predicting FA in the cingulum (cingulate gyrus), AD in the anterior corona radiata and genu of the corpus callosum, and RD in the corona radiata, anterior corona radiata, and genu of corpus callosum. Subjective quality was not important in this subgroup analysis. In summary, chronotype predicted altered WM integrity in the corona radiata and corpus callosum, whereas subjective sleep quality had a less significant role, suggesting that circadian factors may play a more prominent role in WM integrity in emerging mood disorders. Chronotype and subjective sleep quality have been linked to white matter alterations in several populations. We tested whether these factors predict white matter integrity in a transdiagnostic sample of youth in the early phases of mental disorders. Using machine learning, we find that chronotype (but not subjective sleep quality) is a top-ranked predictor of white matter integrity in youth with mood disorders, particularly in the corpus callosum and corona radiata. image
引用
收藏
页码:3322 / 3336
页数:15
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