Cervical Cancer Associated with Pregnancy: Current Challenges and Future Strategies

Simple Summary Cervical cancer occurring during pregnancy represents a rare and challenging situation and requires multidisciplinary care. Both diagnosis and treatment should take into consideration maternal and fetal health, while not compromising the chances for cure. Currently, guidelines for the management of cervical cancer occurring during pregnancy are provided by international consensus meetings with expert panels. However, the current guidelines do not discuss the various approaches that can be found within the literature, such as alternative staging modalities or innovative surgical approaches. Our systematic review, performed with the "Cancer Associe a La Grossesse" (CALG) network, aims to fill the gap on current issues, including both neoadjuvant chemotherapy and surgical strategies to preserve fertility.Abstract Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer without compromising its chances for cure, while preserving the pregnancy and the health of the fetus and child. To date, guidelines for gynecological cancers are provided through international consensus meetings with expert panels, giving insights on both diagnosis, treatment, and obstetrical care. However, these expert guidelines do not discuss the various approaches than can be found within the literature, such as alternative staging modalities or innovative surgical approaches. Also, the obstetrical care of women diagnosed with cervical cancer during pregnancy requires specific considerations that are not provided within our current standard of care. This systematic review aims to fill the gap on current issues with regards to the management of cervical cancer during pregnancy and provide future directions within this evolving landscape.