A survey of preferences and expectations for surgical interventions targeting atonic seizures in Lennox-Gastaut syndrome

PurposeTo assess preferences and outcome expectations for vagus nerve stimulation (VNS) and corpus callosotomy (CC) surgeries in the treatment of atonic seizure in Lennox-Gastaut syndrome (LGS).MethodsA total of 260 surveys were collected from patients are caregivers of LGS patients via Research Electronic Data Capture (REDCap).ResultsRespondents reported an average acceptable atonic seizure reduction rate of 55.9% following VNS and 74.7% following CC. 21.3% (n = 50) were willing to be randomized. Respondents reported low willingness for randomization and a higher seizure reduction expectation with CC.ConclusionOur findings guide surgical approaches for clinicians to consider patient preference in order to design future studies comparing effectiveness between these two procedures.