Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms

被引：0

作者：

Winter, Susann ^{[1
]}

Schneider, Marie ^{[2
]}

Oelschlaegel, Uta ^{[1
]}

Maggioni, Giulia ^{[3
,4
]}

Riva, Elena ^{[3
,4
]}

Raddi, Marco Gabriele ^{[5
]}

Bencini, Sara ^{[6
]}

Peruzzi, Benedetta ^{[6
]}

Choy, Desmond ^{[3
]}

Antunes Dos Reis, Rita ^{[3
]}

Guese, Esther ^{[7
,8
]}

Lischer, Christopher ^{[7
,8
]}

Vera, Julio ^{[7
,8
]}

Timms, Jessica A. ^{[3
]}

Sompairac, Nicolas ^{[3
]}

Sockel, Katja ^{[1
]}

Poloni, Antonella ^{[9
]}

Tunger, Antje ^{[10
,11
,12
,13
,14
,15
]}

Della Porta, Matteo Giovanni ^{[4
,16
]}

Santini, Valeria ^{[5
]}

Schmitz, Marc ^{[10
,11
,12
,13
,14
,15
,17
,18
]}

Platzbecker, Uwe ^{[2
,17
,18
,19
]}

Kordasti, Shahram ^{[3
,9
,20
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Fac Med Carl Gustav Carus, Dept Internal Med 1, Dresden, Germany

[2] Univ Leipzig Med Ctr, Dept Hematol Cellular Therapy & Hemostaseol & Inf, Leipzig, Germany

[3] Kings Coll London, Comprehens Canc Ctr, Sch Canc & Pharmaceut Sci, London, England

[4] IRCCS Humanitas Res Hosp, Milan, Italy

[5] Univ Florence, AOU Careggi Dept Expt & Clin Med, MDS Unit, Hematol, Florence, Italy

[6] AOU Careggi, Flow Cytometry Diagnost Ctr & Immunotherapy CDCI, Florence, Italy

[7] Friedrich Alexander Univ Erlangen Nurnberg, Lab Syst Tumor Immunol, Univ klinikum Erlangen, Erlangen, Germany

[8] Comprehens Canc Ctr Erlangen EMN, Deutsch Zent Immuntherapie, Erlangen, Germany

[9] Univ Politecn Marche, Dept Clin & Mol Sci, Ancona, Italy

[10] Tech Univ Dresden, Inst Immunol, Fac Med Carl Gustav Carus, Dresden, Germany

[11] Natl Ctr Tumor Dis NCT, Dresden, Germany

[12] Tech Univ Dresden, German Canc Res Ctr DKFZ, Dresden, Germany

[13] Tech Univ Dresden, Fac Med, Dresden, Germany

[14] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[15] Helmholtz Zentrum Dresden Rossendorf HZDR, Dresden, Germany

[16] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[17] German Canc Consortium DKTK, Partner Site Dresden, Heidelberg, Germany

[18] German Canc Res Ctr, Heidelberg, Germany

[19] German MDS Study Grp D MDS, Leipzig, Germany

[20] Guys Hosp, Haematol Dept, London, England

来源：

LEUKEMIA | 2024年 / 38卷 / 06期

关键词：

IMMUNOSUPPRESSIVE THERAPY; MDS;

D O I：

10.1038/s41375-024-02249-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1427 / 1431

页数：5

共 35 条

[1] Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1
Trsova, Iva
Hrustincova, Andrea
Krejcik, Zdenek
Kundrat, David
Holoubek, Ales
Staflova, Karolina
Janstova, Lucie
Vanikova, Sarka
Szikszai, Katarina
Klema, Jiri
Rysavy, Petr
Belickova, Monika
Kaisrlikova, Monika
Vesela, Jitka
Cermak, Jaroslav
Jonasova, Anna
Dostal, Jiri
Fric, Jan
Musil, Jan
Merkerova, Michaela Dostalova
MOLECULAR ONCOLOGY, 2023, 17 (12) : 2565 - 2583
[2] Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
Malcovati, Luca
Papaemmanuil, Elli
Bowen, David T.
Boultwood, Jacqueline
Della Porta, Matteo G.
Pascutto, Cristiana
Travaglino, Erica
Groves, Michael J.
Godfrey, Anna L.
Ambaglio, Ilaria
Galli, Anna
Da Via, Matteo C.
Conte, Simona
Tauro, Sudhir
Keenan, Norene
Hyslop, Ann
Hinton, Jonathan
Mudie, Laura J.
Wainscoat, James S.
Futreal, P. Andrew
Stratton, Michael R.
Campbell, Peter J.
Hellstrom-Lindberg, Eva
Cazzola, Mario
BLOOD, 2011, 118 (24) : 6239 - 6246
[3] SF3B1, RUNX1 and TP53 Mutations Significantly Impact the Outcome of Patients With Lower-Risk Myelodysplastic Syndrome
Falantes, Jose F.
Marquez-Malaver, Francisco J.
Carrillo, Estrella
Garcia Culebras, Marta
Morales, Rosario
Prats, Concepcion
Vargas, Maria T.
Caballero, Teresa
Rodriguez-Arboli, Eduardo
Espigado, Ildefonso
Perez-Simon, Jose Antonio
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 (12): : E1059 - E1066
[4] SF3B1, RUNX1 and TP53 Mutations Significantly Impact the Outcome of Patients with Lower-Risk Myelodysplastic Syndrome
Falantes, Jose F.
Marquez-Malaver, Francisco J.
Carrillo-Cruz, Estrella
Morales-Camacho, Rosario M.
Prats-Martin, Concepcion
Caballero, Teresa
Rodriguez Arboli, Eduardo
Espigado, Ildefonso
Perez-Simon, Jose A.
BLOOD, 2022, 140 : 6920 - 6922
[5] Different Mutations in SF3B1 Gene Have Specific Transcriptomic Characteristics in Myelodysplastic Neoplasms
Trsova, Paneliva
Hrustincova, Andrea
Belickova, Monika
Kaisrlikova, Monika
Lenertova, Zuzana
Kundrat, David
Krejcik, Zdenek
Vesela, Jitka
Cermak, Jaroslav
Jonasova, Anna
Merkerova, Michaela Dostalova
BLOOD, 2023, 142
[6] Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
Harbour, J. William
Roberson, Elisha D. O.
Anbunathan, Hima
Onken, Michael D.
Worley, Lori A.
Bowcock, Anne M.
NATURE GENETICS, 2013, 45 (02) : 133 - 135
[7] Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
J William Harbour
Elisha D O Roberson
Hima Anbunathan
Michael D Onken
Lori A Worley
Anne M Bowcock
Nature Genetics, 2013, 45 : 133 - 135
[8] Real-world diagnostic testing patterns for assessment of ring sideroblasts and SF3B1 mutations in patients with newly diagnosed lower-risk myelodysplastic syndromes
Patel, Jay L.
Abedi, Mehrdad
Cogle, Christopher R.
Erba, Harry P.
Foucar, Kathryn
Garcia-Manero, Guillermo
Grinblatt, David L.
Komrokji, Rami S.
Kurtin, Sandra E.
Maciejewski, Jaroslaw P.
Pollyea, Daniel A.
Revicki, Dennis A.
Roboz, Gail J.
Savona, Michael R.
Scott, Bart L.
Sekeres, Mikkael A.
Steensma, David P.
Thompson, Michael A.
Flick, Elizabeth Dawn
Kiselev, Pavel
Louis, Chrystal U.
Nifenecker, Melissa
Swern, Arlene S.
George, Tracy, I
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2021, 43 (03) : 426 - 432
[9] Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
Liu, Zhaoqi
Yoshimi, Akihide
Wang, Jiguang
Cho, Hana
Lee, Stanley Chun-Wei
Ki, Michelle
Bitner, Lillian
Chu, Timothy
Shah, Harshal
Liu, Bo
Mato, Anthony R.
Ruvolo, Peter
Fabbri, Giulia
Pasqualucci, Laura
Abdel-Wahab, Omar
Rabadan, Raul
CANCER DISCOVERY, 2020, 10 (06) : 806 - 821
[10] Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization
Yoshimi, Akihide
Liu, Zhaoqi
Wang Jiguang
Cho, Hana
Lee, Stanley C.
Ki, Michelle
Bitner, Lillian E.
Chu, Timothy
Mato, Anthony R.
Ruvolo, Peter P.
Fabbri, Giulia
Pasqualucci, Laura
Rabadan, Raul
Abdel-Wahab, Omar I.
BLOOD, 2018, 132

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