Cell-penetrating peptides for transmucosal delivery of proteins

被引：13

作者：

Wu, Jiamin ^{[1
]}

Roesger, Sophie ^{[1
]}

Jones, Natalie ^{[1
]}

Hu, Che-Ming J. ^{[2
]}

Li, Shyh-Dar ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada

[2] Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan

来源：

JOURNAL OF CONTROLLED RELEASE | 2024年 / 366卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

Cell -penetrating peptides (CPPs); Proteins; Peptides; Transmucosal delivery; Intranasal; Buccal and sublingual; Oral; TO-BRAIN DELIVERY; DRUG-DELIVERY; TRANSDUCTION DOMAIN; NASAL DELIVERY; INTRANASAL DELIVERY; GUT MICROBIOTA; BARRIER; ABSORPTION; MECHANISMS; STRATEGIES;

D O I：

10.1016/j.jconrel.2024.01.038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enabling non-invasive delivery of proteins across the mucosal barriers promises improved patient compliance and therapeutic efficacies. Cell-penetrating peptides (CPPs) are emerging as a promising and versatile tool to enhance protein and peptide permeation across various mucosal barriers. This review examines the structural and physicochemical attributes of the nasal, buccal, sublingual, and oral mucosa that hamper macromolecular delivery. Recent development of CPPs for overcoming those mucosal barriers for protein delivery is summarized and analyzed. Perspectives regarding current challenges and future research directions towards improving noninvasive transmucosal delivery of macromolecules for ultimate clinical translation are discussed.

引用

页码：864 / 878

页数：15

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