Based on the work-home resource model (ten Brummelhuis & Bakker by American Psychologist, 67, 545-556, 2012), this study investigates the impact of goal alignment for work-from-home (WFH) on personal and family well-being, turnover intention, and the mediating role of work engagement between these relationships. Moreover, we explore whether gender differences moderate the proposed research model. We recruited 701 residents in Singapore to complete an online questionnaire. Our findings suggest that WFH goal alignment is positively associated with personal and family well-being but negatively associated with turnover intention. Furthermore, work engagement significantly mediates the relationship between WFH goal alignment and turnover intention. Finally, we discuss the implications of gender differences in the research model. This study highlights the importance of goal alignment in achieving personal and family well-being and reducing turnover intention and emphasises the role of work engagement in mediating these relationships.