Synthesis and Crystal Structure of (E)-2-phenyl-6,7dihydrobenzofuran-4(5H)-one O-cyanomethyl Oxime

被引：2

作者：

金蕾 ^{[1
]}

方胡彪 ^{[1
]}

曹成桥 ^{[1
]}

黄年玉 ^{[1
]}

邹坤 ^{[1
]}

汪鋆植 ^{[1
,2
]}

机构：

[1] Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University

[2] Hubei Tujia Institute of Medicine

来源：

结构化学 | 2013年 / 32卷 / 09期

基金：

中国国家自然科学基金;

关键词：

X-ray diffraction; crystal structure; oxime ether; H+/K+-ATPase inhibitory activity; cytotoxic activity;

D O I：

暂无

中图分类号：

O782 [晶体生长工艺];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data: monoclinic system,space group P21 /c,a = 8.423(8),b = 19.596(16),c = 8.770(8),β = 107.750(12)°,V = 1379(2)3,Z = 4,F(000) = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections(Rint = 0.0782) and 2428 observed ones(I > 2σ(I)).

引用

页码：1334 / 1338

页数：5

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