Synthesis and Crystal Structure of (E)-2-phenyl-6,7dihydrobenzofuran-4(5H)-one O-cyanomethyl Oxime

被引：2
|
作者：
金蕾 [1 ]
方胡彪 [1 ]
曹成桥 [1 ]
黄年玉 [1 ]
邹坤 [1 ]
汪鋆植 [1 ,2 ]
机构：
[1] Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University
[2] Hubei Tujia Institute of Medicine
来源：
结构化学 | 2013年 / 32卷 / 09期
基金：
中国国家自然科学基金;
关键词：
X-ray diffraction; crystal structure; oxime ether; H+/K+-ATPase inhibitory activity; cytotoxic activity;
D O I：
暂无
中图分类号：
O782 [晶体生长工艺];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data: monoclinic system,space group P21 /c,a = 8.423(8),b = 19.596(16),c = 8.770(8),β = 107.750(12)°,V = 1379(2)3,Z = 4,F(000) = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections(Rint = 0.0782) and 2428 observed ones(I > 2σ(I)).
引用
收藏
页码：1334 / 1338
页数：5
相关论文
共 50 条
  • [1] Synthesis and Crystal Structure of (E)-2-phenyl-6,7-dihydrobenzofuran-4(5H)-one O-cyanomethyl Oxime
    Jin Lei
    Fang Hu-Biao
    Cao Cheng-Qiao
    Huang Nian-Yu
    Zou Kun
    Wang Jun-Zhi
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2013, 32 (09) : 1334 - 1338
  • [2] Synthesis and H+/K+-ATPase Inhibitory Activity of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one Oxime Ether Derivatives
    Fang, Hubiao
    Jin, Lei
    Zai, Weichen
    Song, Yurong
    Wang, Junzhi
    Huang, Nianyu
    ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5, 2013, 634-638 : 1192 - 1195
  • [3] Solvent-free Synthesis and Crystal Structure of 2,2′-Dialkyl Bis(3-methyl-6,7-dihydrobenzofuran-4(5H)-one) Derivatives
    Ding Ze-Jian
    Zhang Feng
    Xu Tian-Xiao
    Wang Wen-Bin
    Jin Lei
    Huang Nian-Yu
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2017, 36 (07) : 1124 - 1129
  • [4] Solvent-free Synthesis and Crystal Structure of 2,2?-Dialkyl Bis(3-methyl-6,7-dihydrobenzofuran-4(5H)-one) Derivatives
    丁泽鉴
    张锋
    徐天笑
    王文彬
    金蕾
    黄年玉
    结构化学, 2017, 36 (07) : 1124 - 1129
  • [5] 6,7-DIHYDRO-6,6-DIMETHYLBENZOFURAZAN-4(5H)-ONE OXIME
    CALLERI, M
    CHIARI, G
    VITERBO, D
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1978, 34 (SEP): : 2953 - 2955
  • [6] A straightforward synthesis of 2(3),6,6-trimethyl-6,7-dihydrobenzofuran-4(5H)-ones
    Yusifov, Niftali N.
    Ismayilov, Valeh M.
    Sadigova, Nurlana D.
    Kopylovich, Maximilian N.
    Mahmudov, Kamran T.
    MENDELEEV COMMUNICATIONS, 2013, 23 (05) : 292 - 293
  • [7] 2-(Alkylamino)-3-aryl-6,7-dihydrobenzofuran-4(5H)-ones: Improved Synthesis and their Photophysical Properties
    Kumar, Manoj
    Kumawat, Lokesh Kumar
    Gupta, Vinod Kumar
    Sharma, Anuj
    CHEMISTRYOPEN, 2015, 4 (05): : 626 - 632
  • [8] Crystal structure and the magnetic anisotropy of CuSO(4)5H(2)O
    Krishnan, KS
    Mookherji, A
    NATURE, 1937, 140 : 896 - 897
  • [9] OXIME OF 6,7-DIHYDRO-6,6-DIMETHYLBENZOFURAZAN-4(5H)-ONE 3-OXIDE
    CALLERI, M
    BONACCORTI, L
    VITERBO, D
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1977, 33 (NOV): : 3546 - 3548
  • [10] The crystal structure of 5-phenyl-3,5-diethoxy-2(5H)-furanone(C14H16O4)
    Pei, WW
    Yu, BT
    Wang, P
    Sun, GB
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2001, 20 (05) : 418 - 420
12345