Complicated evolutionary patterns of microRNAs in vertebrates

被引:0
|
作者
WANG XiaoWo
机构
基金
中国国家自然科学基金;
关键词
microRNA; evolution; miRNA:miRNA* interconversion; lineage specific duplication;
D O I
暂无
中图分类号
Q953 [动物遗传学];
学科分类号
071007 ; 090501 ;
摘要
MicroRNAs (miRNAs) are a class of ~22 nt long endogenous non-coding RNAs that play important regulatory roles in diverse organisms. Up to now, little is known about the evolutionary properties of these crucial regulators. Most miRNAs were thought to be phylogenetically conserved, but recently, a number of poorly-conserved miRNAs have been reported and miRNA innovation is shown to be an ongoing process. In this work, through the characterization of an miRNA super family, we studied the evolutionary patterns of miRNAs in vertebrates. Recently generated miRNAs seem to evolve rapidly during a certain period following their emergence. Multiple lineage-specific expansions were observed. Homolgous premiRNAs may produce mature products from the opposite stem arms following tandem duplications, which may have important contribution to miRNA innovation. Our observations of miRNAs’ complicated evolutionary patterns support the notion that these key regulatory molecules may play very active roles in evolution.
引用
收藏
页码:552 / 559
页数:8
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