Realgar(α-As4S4) Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation

被引：0
|
作者：
ZHANG Miao [1 ]
ZHANG Jia-yi [2 ]
SUN Ming-qian [1 ]
LU Peng [3 ]
LIU Jian-xun [1 ]
机构：
[1] Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences and Beijing Key Lab of Traditional Chinese Medicine Pharmacology
[2] Education Sector, Xiyuan Hospital, China Academy of Chinese Medical Sciences
[3] Medical Administration Division, Xiyuan Hospital, China Academy of Chinese Medical Sciences
来源：
Chinese Journal of Integrative Medicine | 2022年 / 03期
关键词：
D O I：
暂无
中图分类号：
R551.3 [骨髓疾病];
学科分类号：
摘要：
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene silencing.Realgar(α-AsS) is a traditional medicine used for the treatment of various diseases in the ancient time.Realgar was reported to have efficacy for acute promyelocytic leukemia(APL). It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of MDS.This review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS, as well as the species and metabolisms of arsenic in vivo.
引用
收藏
页码：281 / 288
页数：8
相关论文
共 50 条
  • [11] Core level electron binding energies of realgar (AS4S4)
    Pratt, AR
    Nesbitt, HW
    AMERICAN MINERALOGIST, 2000, 85 (3-4) : 619 - 622
  • [12] Mechanochemical preparation and anticancer effect of realgar As4S4 nanoparticles
    Balaz, Peter
    Fabian, Martin
    Pastorek, Michal
    Cholujova, Danka
    Sedlak, Jan
    MATERIALS LETTERS, 2009, 63 (17) : 1542 - 1544
  • [13] Anticancer effects of realgar As4S4 particles prepared by nanomilling
    Balaz, P.
    Fabian, M.
    Pastorek, M.
    Cholujova, D.
    Sedlak, J.
    ARSENIC IN GEOSPHERE AND HUMAN DISEASES, 2010, : 350 - 351
  • [14] Particle properties and their modification in mechanically activated realgar As4S4
    Balaz, Peter
    Dutkova, Erika
    Satka, Alexander
    Kovac, Jaroslav
    ACTA MONTANISTICA SLOVACA, 2011, 16 (02) : 149 - 153
  • [15] Valence and core-level binding energy shifts in realgar (As4S4) and pararealgar (As4S4) arsenic sulfides
    Bullen, HA
    Dorko, MJ
    Oman, JK
    Garrett, SJ
    SURFACE SCIENCE, 2003, 531 (03) : 319 - 328
  • [16] A review of cinnabar (HgS) and/or realgar (As4S4)-containing traditional medicines
    Liu, Jie
    Wei, Li-Xin
    Wang, Qi
    Lu, Yuan-Fu
    Zhang, Feng
    Shi, Jing-Zhen
    Li, Cen
    Cherian, M. George
    JOURNAL OF ETHNOPHARMACOLOGY, 2018, 210 : 340 - 350
  • [17] The medicinal use of realgar (As4S4) and its recent development as an anticancer agent
    Wu, Jinzhu
    Shao, Yanbin
    Liu, Jialiang
    Chen, Gang
    Ho, Paul C.
    JOURNAL OF ETHNOPHARMACOLOGY, 2011, 135 (03) : 595 - 602
  • [18] Realgar (As4S4) bioprecipitation in microcosm fed by a natural groundwater and organic matter
    Lukáš Falteisek
    Vojtěch Duchoslav
    Petr Drahota
    Environmental Science and Pollution Research, 2019, 26 : 18766 - 18776
  • [19] Free volume structure of realgar α-As4S4 by positron annihilation lifetime spectroscopy
    Shpotyuk, O.
    Ingram, A.
    Demchenko, P.
    JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 2015, 79 : 49 - 54
  • [20] MASS-SPECTROMETRIC AND VAPOR PRESSURE STUDIES ON SUBLIMATION OF REALGAR (AS4S4)
    MUNIR, ZA
    STREET, GB
    WINTERS, HF
    JOURNAL OF CHEMICAL PHYSICS, 1971, 55 (09): : 4520 - &
12345