Realgar(α-As4S4) Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation

被引：0
|
作者：
ZHANG Miao [1 ]
ZHANG Jia-yi [2 ]
SUN Ming-qian [1 ]
LU Peng [3 ]
LIU Jian-xun [1 ]
机构：
[1] Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences and Beijing Key Lab of Traditional Chinese Medicine Pharmacology
[2] Education Sector, Xiyuan Hospital, China Academy of Chinese Medical Sciences
[3] Medical Administration Division, Xiyuan Hospital, China Academy of Chinese Medical Sciences
来源：
Chinese Journal of Integrative Medicine | 2022年 / 03期
关键词：
D O I：
暂无
中图分类号：
R551.3 [骨髓疾病];
学科分类号：
摘要：
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene silencing.Realgar(α-AsS) is a traditional medicine used for the treatment of various diseases in the ancient time.Realgar was reported to have efficacy for acute promyelocytic leukemia(APL). It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of MDS.This review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS, as well as the species and metabolisms of arsenic in vivo.
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页码：281 / 288
页数：8
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