Tuning beneficial calcineurin phosphatase activation to counter α-synuclein toxicity in a yeast model of Parkinson's disease

被引：0

作者：

Srishti Chawla ^{[1
,2
]}

Mikael Molin ^{[2
]}

Thomas Nystrom ^{[1
]}

机构：

[1] Institute for Biomedicine,Sahlgrenska Academy,Centre for Ageing and Health-Age Cap,University of Gothenburg

[2] Department of Life Sciences,Chalmers University of Technology

来源：

Neural Regeneration Research | 2025年 / 01期

关键词：

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

Calcineurin(CN) is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast, filamentous fungi, plants, and mammals. Its biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated T-cells. CN is a heterodimeric protein consisting of a catalytic subunit,

引用

页码：199 / 200

页数：2

共 50 条

[11] α-synuclein immunization in a model of Parkinson's disease
不详
NEUROSCIENTIST, 2005, 11 (06): : 523 - 523
[12] GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease
Schneider, Jay S.
Aras, Radha
Williams, Courtney K.
Koprich, James B.
Brotchie, Jonathan M.
Singh, Vikrant
SCIENTIFIC REPORTS, 2019, 9 (1)
[13] GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease
Jay S. Schneider
Radha Aras
Courtney K. Williams
James B. Koprich
Jonathan M. Brotchie
Vikrant Singh
Scientific Reports, 9
[14] Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease
Lee, Yong Joo
Wang, Shaoxiao
Slone, Sunny R.
Yacoubian, Talene A.
Witt, Stephan N.
PLOS ONE, 2011, 6 (01):
[15] Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease
Melo, Thaiany Q.
Palma, Flavio R.
Gomes, Fernando
Netto, Luis E. S.
Ferrari, Merari F. R.
MOLECULAR AND CELLULAR NEUROSCIENCE, 2022, 122
[16] Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
Tenreiro, Sandra
Reimao-Pinto, Madalena M.
Antas, Pedro
Rino, Jose
Wawrzycka, Donata
Macedo, Diana
Rosado-Ramos, Rita
Amen, Triana
Waiss, Meytal
Magalhaes, Filipa
Gomes, Andreia
Santos, Claudia N.
Kaganovich, Daniel
Outeiro, Tiago Fleming
PLOS GENETICS, 2014, 10 (05):
[17] PMSF and SFN Reduce Alpha-synuclein Aggregation in a Yeast Model of Parkinson's Disease
Kozub, Noah J.
Luden, Devyn E.
Furey, Daniel P.
Haak, Victoria M.
Sexton, Zachary
Austriaco, Nicanor
FASEB JOURNAL, 2022, 36
[18] Nicotine slows down oligomerisation of α-synuclein and ameliorates cytotoxicity in a yeast model of Parkinson's disease
Kardani, Jay
Sethi, Ratnika
Roy, Ipsita
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (06): : 1454 - 1463
[19] Association of Glial Activation and α-Synuclein Pathology in Parkinson’s Disease
Rui Wang
Haigang Ren
Elena Kaznacheyeva
Xiaojun Lu
Guanghui Wang
Neuroscience Bulletin, 2023, 39 : 479 - 490
[20] Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease
Grozdanov, Veselin
Bousset, Luc
Hoffmeister, Meike
Bliederhaeuser, Corinna
Meier, Christoph
Madiona, Karine
Pieri, Laura
Kiechle, Martin
McLean, Pamela J.
Kassubek, Jan
Behrends, Christian
Ludolph, Albert C.
Weishaupt, Jochen H.
Melki, Ronald
Danzer, Karin M.
ANNALS OF NEUROLOGY, 2019, 86 (04) : 593 - 606

← 1 2 3 4 5 →