DETERMINATION OF AZTREONAM BY LIQUID-CHROMATOGRAPHY WITH UV AND AMPEROMETRIC DETECTION

被引：9
|
作者：
HUANG, XJ [1 ]
KOK, WT [1 ]
FABRE, H [1 ]
机构：
[1] FAC PHARM MONTPELLIER, CHIM ANALIT LAB, F-34060 MONTPELLIER, FRANCE
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 14期
关键词：
D O I：
10.1080/01483919108049351
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A comparative study of UV and amperometric detection of aztreonam after HPLC separation is presented. At pH 2.0 and a detection potential of +1.15 V (vs. Ag/AgCl), the detection limits with amperometric detection are about two times higher (3-5 ng) than those obtained with UV detection (1-3 ng) for aztreonam and its main decomposition products, the E-isomer and open-ring aztreonam. With the advantage of specificity for the aminothiazole group of the aztreonam molecule, amperometry can be used as an alternative or complementary mode to UV detection for the determination of aztreonam in injectable formulations and in human serum.
引用
收藏
页码：2721 / 2733
页数：13
相关论文
共 50 条
  • [41] DETERMINATION OF TOLUENE DIISOCYANATE IN AIR USING MICRO LIQUID-CHROMATOGRAPHY WITH UV-DETECTION
    BRUNMARK, P
    DALENE, M
    SANGO, C
    SKARPING, G
    ERLANDSSON, P
    DEWAELE, C
    JOURNAL OF MICROCOLUMN SEPARATIONS, 1991, 3 (04) : 371 - 375
  • [42] QUANTITATIVE-DETERMINATION OF PERTECHNETATE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH UV DETECTION
    ZODDA, JP
    HEINEMAN, WR
    GILBERT, TW
    DEUTSCH, E
    JOURNAL OF CHROMATOGRAPHY, 1982, 227 (01): : 249 - 255
  • [43] DETERMINATION OF MORPHINE BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    WALLACE, JE
    HARRIS, SC
    PEEK, MW
    ANALYTICAL CHEMISTRY, 1980, 52 (08) : 1328 - 1330
  • [44] DETERMINATION OF SELENIUM BY LIQUID-CHROMATOGRAPHY WITH SPECTROFLUORIMETRIC DETECTION
    SHIBATA, Y
    MORITA, M
    FUWA, K
    ANALYTICAL CHEMISTRY, 1984, 56 (08) : 1527 - 1530
  • [45] DETERMINATION OF INDOLES AND CATECHOLS IN RAT-BRAIN AND PINEAL USING LIQUID-CHROMATOGRAPHY WITH FLUOROMETRIC AND AMPEROMETRIC DETECTION
    ANDERSON, GM
    YOUNG, JG
    BATTER, DK
    YOUNG, SN
    COHEN, DJ
    SHAYWITZ, BA
    JOURNAL OF CHROMATOGRAPHY, 1981, 223 (02): : 315 - 320
  • [46] DETERMINATION OF SUGARS IN UNCONCENTRATED SEAWATER AND OTHER NATURAL-WATERS BY LIQUID-CHROMATOGRAPHY AND PULSED AMPEROMETRIC DETECTION
    MOPPER, K
    SCHULTZ, CA
    CHEVOLOT, L
    GERMAIN, C
    REVUELTA, R
    DAWSON, R
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1992, 26 (01) : 133 - 138
  • [47] CHROMATOGRAPHIC APPROACHES TO SIGNAL AND SELECTIVITY ENHANCEMENT FOR DETERMINATION OF BIOGENIC-AMINES BY LIQUID-CHROMATOGRAPHY WITH AMPEROMETRIC DETECTION
    MEFFORD, IN
    LIFE SCIENCES, 1987, 41 (07) : 893 - 896
  • [48] LIQUID-CHROMATOGRAPHY ON SMALL DIAMETER COLUMNS ASSOCIATED WITH DUAL AMPEROMETRIC DETECTION
    BEAUCHAMP, R
    BEAUDAN, BJ
    MOUNOUSSAMY, J
    ANALUSIS, 1985, 13 (06) : 286 - 291
  • [49] DETERMINATION OF TYRAMINE IN CHEESE BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH AMPEROMETRIC DETECTION
    TAKEBA, K
    MARUYAMA, T
    MATSUMOTO, M
    NAKAZAWA, H
    JOURNAL OF CHROMATOGRAPHY, 1990, 504 (02): : 441 - 444
  • [50] DETERMINATION OF THIRAM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH AMPEROMETRIC DETECTION IN RIVER WATER AND FUNGICIDE FORMULATIONS
    UBEDA, MR
    ESCRIBANO, MTS
    HERNANDEZ, LH
    MICROCHEMICAL JOURNAL, 1990, 41 (01) : 22 - 28
12345