ACETYLCHOLINE OUTPUT AND MATERNO-FETAL ALPHA-AMINOISOBUTYRIC-ACID TRANSFER IN THE PERFUSED HUMAN PLACENTAL LOBULE

被引：11
|
作者：
KRISHNA, BR [1 ]
KING, RG [1 ]
BRENNECKE, SP [1 ]
机构：
[1] MONASH UNIV,DEPT OBSTET & GYNAECOL,MONASH PERINATAL UNIT,CLAYTON,VIC 3168,AUSTRALIA
来源：
REPRODUCTION FERTILITY AND DEVELOPMENT | 1991年 / 3卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1071/RD9910459
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Dually perfused human placental lobules were employed to study the effects of vesamicol (an inhibitor of acetylcholine (ACh) storage) and physostigmine (an inhibitor of cholinesterase breakdown of ACh) on ACh output from fetal vessels and on materno-fetal transfer of the nonmetabolizable amino acid alpha-aminoisobutyric acid (AIB). Bilateral perfusion with vesamicol (100-mu-mol L-1) or omission of physostigmine (2-7-mu-mol L-1) from the perfusate significantly reduced the output of ACh. However, neither drug had any significant effect on AIB transfer. Thus, the results of this study do not provide evidence for a close relationship between the placental cholinergic system and materno-fetal AIB transfer.
引用
收藏
页码：459 / 465
页数：7
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